Technology Process of methyl 2-{1-[(benzyloxy)amino]-3-methoxy-1,3-dioxopropan-2-yl}-5-methoxybenzoate
There total 7 articles about methyl 2-{1-[(benzyloxy)amino]-3-methoxy-1,3-dioxopropan-2-yl}-5-methoxybenzoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
5-methoxy-2-methoxycarbonylmethyl-benzoic acid methyl ester;
With
n-butyllithium; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran;
at -78 - 0 ℃;
for 1.16667h;
Inert atmosphere;
With
carbon dioxide;
In
tetrahydrofuran;
for 1h;
N-benzyloxyamine;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: nitric acid / 2 h / 0 - 22 °C
2.1: methanol; hydrogen / 5%-palladium/activated carbon / 0.08 h / 760.05 Torr / Reflux
3.1: sulfuric acid; sodium nitrite / water / 2 h / 0 - 5 °C / Cooling with ice
4.1: thionyl chloride / 24 h / Reflux
4.2: 12 h / Reflux
5.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1.17 h / -78 - 0 °C / Inert atmosphere
5.2: 1 h
With
methanol; n-butyllithium; thionyl chloride; sulfuric acid; hydrogen; nitric acid; N-ethyl-N,N-diisopropylamine; sodium nitrite;
5%-palladium/activated carbon;
In
tetrahydrofuran; water;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: methanol; hydrogen / 5%-palladium/activated carbon / 0.08 h / 760.05 Torr / Reflux
2.1: sulfuric acid; sodium nitrite / water / 2 h / 0 - 5 °C / Cooling with ice
3.1: thionyl chloride / 24 h / Reflux
3.2: 12 h / Reflux
4.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1.17 h / -78 - 0 °C / Inert atmosphere
4.2: 1 h
With
methanol; n-butyllithium; thionyl chloride; sulfuric acid; hydrogen; N-ethyl-N,N-diisopropylamine; sodium nitrite;
5%-palladium/activated carbon;
In
tetrahydrofuran; water;
