C₄H₃OCH₂CH₂CHCHCONCO₂CH₂CHC₆H₅CH₄CH₂

Base Information

• Chemical Name: C₄H₃OCH₂CH₂CHCHCONCO₂CH₂CHC₆H₅CH₄CH₂
• CAS No.: 957794-80-8
• Molecular Formula: C₂₀H₂₃NO₄
• Molecular Weight: 341.407
• Mol file: 957794-80-8.mol

Synonyms:C₄H₃OCH₂CH₂CHCHCONCO₂CH₂CHC₆H₅CH₄CH₂

Chemical Property of C₄H₃OCH₂CH₂CHCHCONCO₂CH₂CHC₆H₅CH₄CH₂

Chemical Property:

Purity/Quality:

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Technology Process of C₄H₃OCH₂CH₂CHCHCONCO₂CH₂CHC₆H₅CH₄CH₂

There total 1 articles about C₄H₃OCH₂CH₂CHCHCONCO₂CH₂CHC₆H₅CH₄CH₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3-[5-(4-methyl-furan-3-yl)-pent-2-enoyl]-4(R)-phenyl-oxazolidin-2-one + methylmagnesium chloride (676-58-4) → C4H3OCH2CH2CHCHCONCO2CH2CHC6H5CH4CH2 (957794-80-8)

Guidance literature:

methylmagnesium chloride; With copper(I) bromide dimethylsulfide complex; dimethylsulfide; In tetrahydrofuran; at -78 - 0 ℃; for 1h;

3-[5-(4-methyl-furan-3-yl)-pent-2-enoyl]-4(R)-phenyl-oxazolidin-2-one; In tetrahydrofuran; dichloromethane; at -78 - -30 ℃; for 3.25h; Further stages.;

DOI:10.1021/ol702118n

Reference yield: 94.0%

C4H3OCH2CH2CHCHCONCO2CH2CHC6H5CH4CH2 (957794-80-8) + triisopropylsilyl trifluoromethanesulfonate (80522-42-5) → 3-[3(R)-methyl-5-(4-methyl-furan-5-yl)-1-triisopropylsilanyloxy-pent-1-enyl]-4(R)-phenyloxazolidin-2-one

Guidance literature:

C₄H₃OCH₂CH₂CHCHCONCO₂CH₂CHC₆H₅CH₄CH₂; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 2.5h;

triisopropylsilyl trifluoromethanesulfonate; In tetrahydrofuran; at -78 ℃; for 2h; Further stages.;

DOI:10.1021/ol702118n

upstream raw materials:

methylmagnesium chloride