6-benzyloxy-3-ethyl-1H-indazole-5-carboxylic acid (4-morpholin-4-yl-phenyl)-N-amino-amidine

Base Information

Chemical Name:6-benzyloxy-3-ethyl-1H-indazole-5-carboxylic acid (4-morpholin-4-yl-phenyl)-N-amino-amidine
CAS No.:1464139-78-3
Molecular Formula:C₂₇H₃₀N₆O₂
Molecular Weight:470.574
Hs Code.:

Synonyms:6-benzyloxy-3-ethyl-1H-indazole-5-carboxylic acid (4-morpholin-4-yl-phenyl)-N-amino-amidine

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Chemical Property of 6-benzyloxy-3-ethyl-1H-indazole-5-carboxylic acid (4-morpholin-4-yl-phenyl)-N-amino-amidine

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Technology Process of 6-benzyloxy-3-ethyl-1H-indazole-5-carboxylic acid (4-morpholin-4-yl-phenyl)-N-amino-amidine

There total 8 articles about 6-benzyloxy-3-ethyl-1H-indazole-5-carboxylic acid (4-morpholin-4-yl-phenyl)-N-amino-amidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1464139-77-2
6-benzyloxy-3-ethyl-1H-indazole-5-carboxylic acid (4-morpholin-4-yl-phenyl)thioamide

: 1464139-78-3
6-benzyloxy-3-ethyl-1H-indazole-5-carboxylic acid (4-morpholin-4-yl-phenyl)-N-amino-amidine

Guidance literature:: With hydrazine; In 1,4-dioxane; for 0.5h; Reflux;

Reference yield:

: 392-04-1
methyl 4-fluoro-2-hydroxybenzoate

: 1464139-78-3
6-benzyloxy-3-ethyl-1H-indazole-5-carboxylic acid (4-morpholin-4-yl-phenyl)-N-amino-amidine

Guidance literature:: Multi-step reaction with 7 steps

1.1: aluminum (III) chloride / dichloromethane / 0.08 h

1.2: Reflux

2.1: sodium carbonate / N,N-dimethyl-formamide / 60 °C

3.1: hydrazine / tetrahydrofuran

4.1: water; sodium hydroxide / tetrahydrofuran / Reflux

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / N,N-dimethyl-formamide

6.1: Lawessons reagent / toluene / 1 h / Reflux

7.1: hydrazine / 1,4-dioxane / 0.5 h / Reflux

With Lawessons reagent; dmap; aluminum (III) chloride; water; sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; hydrazine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1464139-72-7
4-fluoro-2-hydroxy-5-propionyl-benzoic acid methyl ester

: 1464139-78-3
6-benzyloxy-3-ethyl-1H-indazole-5-carboxylic acid (4-morpholin-4-yl-phenyl)-N-amino-amidine

Guidance literature:: Multi-step reaction with 6 steps

1: sodium carbonate / N,N-dimethyl-formamide / 60 °C

2: hydrazine / tetrahydrofuran

3: water; sodium hydroxide / tetrahydrofuran / Reflux

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / N,N-dimethyl-formamide

5: Lawessons reagent / toluene / 1 h / Reflux

6: hydrazine / 1,4-dioxane / 0.5 h / Reflux

With Lawessons reagent; dmap; water; sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; hydrazine; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; toluene;