C₁₆H₁₈F₄O₂

Base Information

Chemical Name:C₁₆H₁₈F₄O₂
CAS No.:1562399-32-9
Molecular Formula:C₁₆H₁₈F₄O₂
Molecular Weight:318.311
Hs Code.:

C<sub>16</sub>H<sub>18</sub>F<sub>4</sub>O<sub>2</sub>

Synonyms:C₁₆H₁₈F₄O₂

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Chemical Property of C₁₆H₁₈F₄O₂

Chemical Property:

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Technology Process of C₁₆H₁₈F₄O₂

There total 8 articles about C₁₆H₁₈F₄O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1,1,1-trifluoro-4-(4-fluoro-2-methoxyphenyl)-4-methylpentan-2-one

: 106-96-7
propargyl bromide

: 1562399-32-9
C₁₆H₁₈F₄O₂

Guidance literature:: propargyl bromide; With aluminium; mercury dichloride; In tetrahydrofuran; toluene; at 20 - 40 ℃; for 2h; Inert atmosphere;

1,1,1-trifluoro-4-(4-fluoro-2-methoxyphenyl)-4-methylpentan-2-one; In tetrahydrofuran; diethyl ether; toluene; at -78 - 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jm4019178

Reference yield:

: 1481-27-2
4-Fluoro-2-hydroxyacetophenone

: 1562399-32-9
C₁₆H₁₈F₄O₂

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2.1: benzylamine; acetic acid / toluene / 16 h / Inert atmosphere; Dean-Stark; Reflux

3.1: copper(l) iodide / diethyl ether / 0.42 h / 0 - 15 °C / Inert atmosphere

3.2: 2.33 h / 20 °C / Inert atmosphere

4.1: sodium chloride / dimethyl sulfoxide; water / 4 h / Inert atmosphere; Reflux

5.1: diisobutylaluminium hydride / dichloromethane / 16 h / -40 - 20 °C / Inert atmosphere

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / Inert atmosphere

7.1: Dess-Martin periodane / dichloromethane / 1 h / Inert atmosphere

8.1: mercury dichloride; aluminium / tetrahydrofuran; toluene / 2 h / 20 - 40 °C / Inert atmosphere

8.2: 2 h / -78 - 20 °C / Inert atmosphere

With copper(l) iodide; tetrabutyl ammonium fluoride; diisobutylaluminium hydride; potassium carbonate; Dess-Martin periodane; acetic acid; aluminium; benzylamine; sodium chloride; mercury dichloride; In tetrahydrofuran; diethyl ether; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm4019178

Reference yield:

: 51788-80-8
1-(4-fluoro-2-methoxy-phenyl)-ethanone

: 1562399-32-9
C₁₆H₁₈F₄O₂

Guidance literature:: Multi-step reaction with 7 steps

1.1: benzylamine; acetic acid / toluene / 16 h / Inert atmosphere; Dean-Stark; Reflux

2.1: copper(l) iodide / diethyl ether / 0.42 h / 0 - 15 °C / Inert atmosphere

2.2: 2.33 h / 20 °C / Inert atmosphere

3.1: sodium chloride / dimethyl sulfoxide; water / 4 h / Inert atmosphere; Reflux

4.1: diisobutylaluminium hydride / dichloromethane / 16 h / -40 - 20 °C / Inert atmosphere

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / Inert atmosphere

6.1: Dess-Martin periodane / dichloromethane / 1 h / Inert atmosphere

7.1: mercury dichloride; aluminium / tetrahydrofuran; toluene / 2 h / 20 - 40 °C / Inert atmosphere

7.2: 2 h / -78 - 20 °C / Inert atmosphere

With copper(l) iodide; tetrabutyl ammonium fluoride; diisobutylaluminium hydride; Dess-Martin periodane; acetic acid; aluminium; benzylamine; sodium chloride; mercury dichloride; In tetrahydrofuran; diethyl ether; dichloromethane; water; dimethyl sulfoxide; toluene;
DOI:10.1021/jm4019178