5-Hydroxy-2-methyl-5-((Z)-6-triisopropylsilanyl-hex-3-ene-1,5-diynyl)-cyclohex-1-enecarboxylic acid ethyl ester

Base Information

Chemical Name:5-Hydroxy-2-methyl-5-((Z)-6-triisopropylsilanyl-hex-3-ene-1,5-diynyl)-cyclohex-1-enecarboxylic acid ethyl ester
CAS No.:213924-80-2
Molecular Formula:C₂₅H₃₈O₃Si
Molecular Weight:414.66
Hs Code.:

Synonyms:5-Hydroxy-2-methyl-5-((Z)-6-triisopropylsilanyl-hex-3-ene-1,5-diynyl)-cyclohex-1-enecarboxylic acid ethyl ester

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Chemical Property of 5-Hydroxy-2-methyl-5-((Z)-6-triisopropylsilanyl-hex-3-ene-1,5-diynyl)-cyclohex-1-enecarboxylic acid ethyl ester

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Technology Process of 5-Hydroxy-2-methyl-5-((Z)-6-triisopropylsilanyl-hex-3-ene-1,5-diynyl)-cyclohex-1-enecarboxylic acid ethyl ester

There total 5 articles about 5-Hydroxy-2-methyl-5-((Z)-6-triisopropylsilanyl-hex-3-ene-1,5-diynyl)-cyclohex-1-enecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 149776-81-8
(Z)-hex-3-en-1,5-diynyl-triisopropylsilane

: 98046-49-2
2-Methyl-5-oxo-cyclohex-1-enecarboxylic acid ethyl ester

: 213924-80-2
5-Hydroxy-2-methyl-5-((Z)-6-triisopropylsilanyl-hex-3-ene-1,5-diynyl)-cyclohex-1-enecarboxylic acid ethyl ester

Guidance literature:: With cerium(III) chloride; tert.-butyl lithium; In tetrahydrofuran; at -78 ℃; for 0.166667h;
DOI:10.1016/S0040-4039(98)01297-0

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 213924-80-2
5-Hydroxy-2-methyl-5-((Z)-6-triisopropylsilanyl-hex-3-ene-1,5-diynyl)-cyclohex-1-enecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 60 percent / LDA, HMPA / tetrahydrofuran / 0.5 h / -78 °C

2: 99 percent / KHMDS / tetrahydrofuran / 1 h / -78 - 21 °C

3: 99 percent / diethyl ether / -78 - 21 °C

4: 80 percent / 35percent aq. CF₃COOH / CHCl₃ / 72 h / 21 °C

5: 84 percent / t-BuLi, CeCl₃ / tetrahydrofuran / 0.17 h / -78 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; cerium(III) chloride; tert.-butyl lithium; potassium hexamethylsilazane; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; chloroform;
DOI:10.1016/S0040-4039(98)01297-0

Reference yield:

: 14160-65-7,77793-24-9,122090-88-4
ethyl 8-oxo-1,4-dioxaspiro[4.5]decane-7-carboxylate

: 213924-80-2
5-Hydroxy-2-methyl-5-((Z)-6-triisopropylsilanyl-hex-3-ene-1,5-diynyl)-cyclohex-1-enecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / KHMDS / tetrahydrofuran / 1 h / -78 - 21 °C

2: 99 percent / diethyl ether / -78 - 21 °C

3: 80 percent / 35percent aq. CF₃COOH / CHCl₃ / 72 h / 21 °C

4: 84 percent / t-BuLi, CeCl₃ / tetrahydrofuran / 0.17 h / -78 °C

With cerium(III) chloride; tert.-butyl lithium; potassium hexamethylsilazane; trifluoroacetic acid; In tetrahydrofuran; diethyl ether; chloroform;
DOI:10.1016/S0040-4039(98)01297-0