(3aR,6aR)-5-iodo-2,2-dimethyl-6-((trityloxy)methyl)-3aH-cyclopenta[d][1,3]dioxol-4(6aH)-one

Base Information

Chemical Name:(3aR,6aR)-5-iodo-2,2-dimethyl-6-((trityloxy)methyl)-3aH-cyclopenta[d][1,3]dioxol-4(6aH)-one
CAS No.:805245-38-9
Molecular Formula:C₂₈H₂₅IO₄
Molecular Weight:552.409
Hs Code.:

Synonyms:(3aR,6aR)-5-iodo-2,2-dimethyl-6-((trityloxy)methyl)-3aH-cyclopenta[d][1,3]dioxol-4(6aH)-one

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Chemical Property of (3aR,6aR)-5-iodo-2,2-dimethyl-6-((trityloxy)methyl)-3aH-cyclopenta[d][1,3]dioxol-4(6aH)-one

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Technology Process of (3aR,6aR)-5-iodo-2,2-dimethyl-6-((trityloxy)methyl)-3aH-cyclopenta[d][1,3]dioxol-4(6aH)-one

There total 14 articles about (3aR,6aR)-5-iodo-2,2-dimethyl-6-((trityloxy)methyl)-3aH-cyclopenta[d][1,3]dioxol-4(6aH)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 88559-56-2
(3aR,6aR)-2,2-dimethyl-6-[(trityloxy)methyl]-3a,6a-dihydro-4H-cyclopenta[d][1,3]dioxol-4-one

: 805245-38-9
(3aR,6aR)-5-iodo-2,2-dimethyl-6-((trityloxy)methyl)-3aH-cyclopenta[d][1,3]dioxol-4(6aH)-one

Guidance literature:: With pyridine; iodine; In dichloromethane; at 0 - 20 ℃; for 6h;

Reference yield:

: (1R,4S,5S)-2-iodo-4,5-isopropylidenedioxy-1-(trityloxymethyl)cyclopent-2-enol

: 805245-38-9
(3aR,6aR)-5-iodo-2,2-dimethyl-6-((trityloxy)methyl)-3aH-cyclopenta[d][1,3]dioxol-4(6aH)-one

Guidance literature:: With aluminum oxide; dipyridinium dichromate; In dichloromethane; at 20 ℃; for 12h; Temperature; Reagent/catalyst; Molecular sieve; Large scale;

Reference yield:

: 54503-64-9,54503-65-0
2,3-O-isopropylidene-5-O-trityl-D-ribofuranose

: 805245-38-9
(3aR,6aR)-5-iodo-2,2-dimethyl-6-((trityloxy)methyl)-3aH-cyclopenta[d][1,3]dioxol-4(6aH)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium tert-butylate / tetrahydrofuran / 1 h / 0 - 20 °C

1.2: 7 h / 0 - 20 °C

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.5 h / -78 °C

2.2: 1 h / -78 - 20 °C

3.1: tetrahydrofuran / 1 h / -78 °C

4.1: tri(cycloxexyl)phosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidene][benzylidene]ruthenium(IV) dichloride / dichloromethane / 48 h / 20 °C

5.1: dipyridinium dichromate / molecular sieve / N,N-dimethyl-formamide / 48 h / 20 °C

6.1: pyridine; iodine / dichloromethane / 6 h / 0 - 20 °C

With pyridine; dipyridinium dichromate; oxalyl dichloride; potassium tert-butylate; iodine; dimethyl sulfoxide; tri(cycloxexyl)phosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidene][benzylidene]ruthenium(IV) dichloride; molecular sieve; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1.1: Wittig Reaction / 2.1: Swern Oxidation / 3.1: Grignard Reaction;