α-(3-methylphenyl)-2-pyridylmethanol

Base Information

• Chemical Name: α-(3-methylphenyl)-2-pyridylmethanol
• CAS No.: 29263-66-9
• Molecular Formula: C₁₃H₁₃NO
• Molecular Weight: 199.252
• Mol file: 29263-66-9.mol

Synonyms:α-(3-methylphenyl)-2-pyridylmethanol

Chemical Property of α-(3-methylphenyl)-2-pyridylmethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of α-(3-methylphenyl)-2-pyridylmethanol

There total 10 articles about α-(3-methylphenyl)-2-pyridylmethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

2-(3-methylbenzyl)pyridine (29263-64-7) → α-(3-methylphenyl)-2-pyridylmethanol (29263-66-9)

Guidance literature:

With potassium tert-butylate; In dimethyl sulfoxide; at 20 ℃; for 0.05h; Green chemistry;

Reference yield: 61.0%

2-(3-methylbenzyl)pyridine (29263-64-7) + dimethyl sulfoxide (67-68-5,8070-53-9) → α-(3-methylphenyl)-2-pyridylmethanol (29263-66-9) + 2-(methylsulfinyl)-1-(pyridin-2-yl)-1-(m-tolyl)ethan-1-ol

Guidance literature:

With potassium tert-butylate; at 30 ℃; for 0.05h; chemoselective reaction;

DOI:10.1021/acs.orglett.0c03108

Reference yield:

pyridine-2-carbaldehyde (1121-60-4) + meta-bromotoluene (591-17-3) → α-(3-methylphenyl)-2-pyridylmethanol (29263-66-9)

Guidance literature:

meta-bromotoluene; With iodine; magnesium; In tetrahydrofuran; at 0 - 20 ℃; for 2h; Inert atmosphere;

pyridine-2-carbaldehyde; In tetrahydrofuran; at 0 ℃; Inert atmosphere;

DOI:10.1002/ejoc.201403233

upstream raw materials:

2-Picolinic acid

m-tolyl aldehyde

(pyridin-2-yl)magnesium bromide

pyridine-2-carbaldehyde

Downstream raw materials:

erythro-α-(3-methylphenyl)-2-piperidylmethanol

threo-α-(3-methylphenyl)-piperidylmethanol

phenyl(pyridin-2-yl)(m-tolyl)methanol

(pyridin-2-yl)(m-tolyl)methanone

Refernces

• 1、 -. "Green synthesis method of polyaryl substituted methanol". Paragraph 0127-0131; 0157-0161. . Retrieved 2021/04/17.
• 2、 Yang, Yuhuan,Gao, Qian,Xu, Senmiao. "Ligand-Free Iridium-Catalyzed Dehydrogenative ortho C?H Borylation of Benzyl-2-Pyridines at Room Temperature". supporting information. p. 858 - 862. Retrieved 2019/01/04.