(4R,5S)-2-(4-methoxyphenyl)-5-methyl-4-((2S,4S)-4-methyldecan-2-yl)-1,3-dioxane

Base Information

Chemical Name:(4R,5S)-2-(4-methoxyphenyl)-5-methyl-4-((2S,4S)-4-methyldecan-2-yl)-1,3-dioxane
CAS No.:1453811-65-8
Molecular Formula:C₂₃H₃₈O₃
Molecular Weight:362.553
Hs Code.:

Synonyms:(4R,5S)-2-(4-methoxyphenyl)-5-methyl-4-((2S,4S)-4-methyldecan-2-yl)-1,3-dioxane

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Chemical Property of (4R,5S)-2-(4-methoxyphenyl)-5-methyl-4-((2S,4S)-4-methyldecan-2-yl)-1,3-dioxane

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Technology Process of (4R,5S)-2-(4-methoxyphenyl)-5-methyl-4-((2S,4S)-4-methyldecan-2-yl)-1,3-dioxane

There total 6 articles about (4R,5S)-2-(4-methoxyphenyl)-5-methyl-4-((2S,4S)-4-methyldecan-2-yl)-1,3-dioxane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1453811-64-7
O-(2R,3S,4S)-2-((4S,5S)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)-4-methyldecan-3-yl (S)-methyl carbonodithioate

: 1453811-65-8
(4R,5S)-2-(4-methoxyphenyl)-5-methyl-4-((2S,4S)-4-methyldecan-2-yl)-1,3-dioxane

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; at 120 ℃; for 0.5h;
DOI:10.1016/j.tetasy.2013.07.012

Reference yield:

: 7786-29-0,49642-49-1,72598-55-1,55352-42-6
(S)-α-methyloctanal

: 1453811-65-8
(4R,5S)-2-(4-methoxyphenyl)-5-methyl-4-((2S,4S)-4-methyldecan-2-yl)-1,3-dioxane

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; dicyclohexylboron chloride / diethyl ether / 2.5 h / -78 - 0 °C

1.2: -78 - 0 °C

2.1: tetramethylammonium triacetoxyborohydride / acetone; acetic acid / 30 h / -20 °C

3.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 0.5 h / 0 °C / Molecular sieve

4.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

4.2: 0.5 h / -78 °C

4.3: 0.08 h / -78 °C

5.1: tri-n-butyl-tin hydride; 2,2'-azobis(isobutyronitrile) / 0.5 h / 120 °C

With 2,2'-azobis(isobutyronitrile); dicyclohexylboron chloride; tri-n-butyl-tin hydride; sodium hexamethyldisilazane; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; tetramethylammonium triacetoxyborohydride; In tetrahydrofuran; diethyl ether; dichloromethane; acetic acid; acetone;
DOI:10.1016/j.tetasy.2013.07.012

Reference yield:

: 1453811-61-4
(2S,4S,5S,6S)-5-hydroxy-1-(4-methoxybenzyloxy)-2,4,6-trimethyldodecan-3-one

: 1453811-65-8
(4R,5S)-2-(4-methoxyphenyl)-5-methyl-4-((2S,4S)-4-methyldecan-2-yl)-1,3-dioxane

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetramethylammonium triacetoxyborohydride / acetone; acetic acid / 30 h / -20 °C

2.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 0.5 h / 0 °C / Molecular sieve

3.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

3.2: 0.5 h / -78 °C

3.3: 0.08 h / -78 °C

4.1: tri-n-butyl-tin hydride; 2,2'-azobis(isobutyronitrile) / 0.5 h / 120 °C

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; sodium hexamethyldisilazane; 2,3-dicyano-5,6-dichloro-p-benzoquinone; tetramethylammonium triacetoxyborohydride; In tetrahydrofuran; dichloromethane; acetic acid; acetone;
DOI:10.1016/j.tetasy.2013.07.012