(2S,4S,5S,6S)-5-hydroxy-1-(4-methoxybenzyloxy)-2,4,6-trimethyldodecan-3-one

Base Information

Chemical Name:(2S,4S,5S,6S)-5-hydroxy-1-(4-methoxybenzyloxy)-2,4,6-trimethyldodecan-3-one
CAS No.:1453811-61-4
Molecular Formula:C₂₃H₃₈O₄
Molecular Weight:378.552
Hs Code.:

Synonyms:(2S,4S,5S,6S)-5-hydroxy-1-(4-methoxybenzyloxy)-2,4,6-trimethyldodecan-3-one

Suppliers and Price of (2S,4S,5S,6S)-5-hydroxy-1-(4-methoxybenzyloxy)-2,4,6-trimethyldodecan-3-one

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Chemical Property of (2S,4S,5S,6S)-5-hydroxy-1-(4-methoxybenzyloxy)-2,4,6-trimethyldodecan-3-one

Chemical Property:

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Technology Process of (2S,4S,5S,6S)-5-hydroxy-1-(4-methoxybenzyloxy)-2,4,6-trimethyldodecan-3-one

There total 1 articles about (2S,4S,5S,6S)-5-hydroxy-1-(4-methoxybenzyloxy)-2,4,6-trimethyldodecan-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 7786-29-0,49642-49-1,72598-55-1,55352-42-6
(S)-α-methyloctanal

: 182193-69-7
(S)-1-(p-methoxybenzyloxy)-2-methylpentan-3-one

: 1453811-61-4
(2S,4S,5S,6S)-5-hydroxy-1-(4-methoxybenzyloxy)-2,4,6-trimethyldodecan-3-one

Guidance literature:: (S)-1-(p-methoxybenzyloxy)-2-methylpentan-3-one; With dicyclohexylboron chloride; triethylamine; In diethyl ether; at -78 - 0 ℃; for 2.5h;

(S)-α-methyloctanal; In diethyl ether; at -78 - 0 ℃;
DOI:10.1016/j.tetasy.2013.07.012

Reference yield: 90.0%

: 1453811-61-4
(2S,4S,5S,6S)-5-hydroxy-1-(4-methoxybenzyloxy)-2,4,6-trimethyldodecan-3-one

: 1453811-63-6
(2S,3S,4S,5S,6S)-1-(4-methoxybenzyloxy)-2,4,6-trimethyldodecane-3,5-diol

Guidance literature:: With tetramethylammonium triacetoxyborohydride; In acetic acid; acetone; at -20 ℃; for 30h;
DOI:10.1016/j.tetasy.2013.07.012

Reference yield:

: 1453811-61-4
(2S,4S,5S,6S)-5-hydroxy-1-(4-methoxybenzyloxy)-2,4,6-trimethyldodecan-3-one

: C₂₇H₄₅NO₆

Guidance literature:: Multi-step reaction with 10 steps

1.1: tetramethylammonium triacetoxyborohydride / acetone; acetic acid / 30 h / -20 °C

2.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 0.5 h / 0 °C / Molecular sieve

3.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

3.2: 0.5 h / -78 °C

3.3: 0.08 h / -78 °C

4.1: tri-n-butyl-tin hydride; 2,2'-azobis(isobutyronitrile) / 0.5 h / 120 °C

5.1: diisobutylaluminium hydride / dichloromethane; toluene / 0.5 h / -78 °C

6.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 0.17 h / 20 °C / Inert atmosphere; Molecular sieve

7.1: potassium tert-butylate / diethyl ether / 0.5 h / 0 - 20 °C

7.2: 0.5 h / 0 °C

8.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / chloroform; water / 0.5 h / 0 °C

9.1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 5 h / 0 - 20 °C

10.1: osmium(VIII) oxide; water; 4-methylmorpholine N-oxide; methanesulfonamide / 1,4-dioxane / 4 h / 0 - 20 °C

With dmap; osmium(VIII) oxide; tetrapropylammonium perruthennate; 2,2'-azobis(isobutyronitrile); methanesulfonamide; potassium tert-butylate; water; tri-n-butyl-tin hydride; sodium hexamethyldisilazane; diisobutylaluminium hydride; 4-methylmorpholine N-oxide; dicyclohexyl-carbodiimide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; tetramethylammonium triacetoxyborohydride; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; chloroform; water; acetic acid; acetone; toluene; 6.1: |Ley Oxidation / 7.1: |Wittig Olefination / 7.2: |Wittig Olefination;
DOI:10.1016/j.tetasy.2013.07.012