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Levocarnitine

Base Information Edit
  • Chemical Name:Levocarnitine
  • CAS No.:541-15-1
  • Deprecated CAS:7634-98-2
  • Molecular Formula:C7H15NO3
  • Molecular Weight:161.201
  • Hs Code.: Oral rats LD50: 14,000 mg/Kg
  • European Community (EC) Number:208-768-0
  • NSC Number:759132,741806
  • UNII:0G389FZZ9M
  • DSSTox Substance ID:DTXSID4023208
  • Wikipedia:Carnitine
  • Wikidata:Q20735709
  • NCI Thesaurus Code:C26657
  • RXCUI:42955
  • Metabolomics Workbench ID:42914
  • ChEMBL ID:CHEMBL1149
  • Mol file:541-15-1.mol
Levocarnitine

Synonyms:Bicarnesine;Carnitine;L Carnitine;L-Carnitine;Levocarnitine;Vitamin BT

Suppliers and Price of Levocarnitine
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • Usbiological
  • D-Carnitine
  • 2.5mg
  • $ 446.00
  • TRC
  • L-Carnitine-13CChloride
  • 1mg
  • $ 155.00
  • TCI Chemical
  • L-Carnitine >98.0%(T)
  • 5g
  • $ 46.00
  • TCI Chemical
  • L-Carnitine >98.0%(T)
  • 25g
  • $ 136.00
  • SynQuest Laboratories
  • (3R)-(-)-3-Hydroxy-4-(trimethylammonio)butanoate 99.0%
  • 250 g
  • $ 132.00
  • SynQuest Laboratories
  • (3R)-(-)-3-Hydroxy-4-(trimethylammonio)butanoate 99.0%
  • 25 g
  • $ 21.00
  • SynQuest Laboratories
  • (3R)-(-)-3-Hydroxy-4-(trimethylammonio)butanoate 99.0%
  • 100 g
  • $ 55.00
  • Sigma-Aldrich
  • L-Carnitine inner salt synthetic, ≥98%
  • 1g
  • $ 40.70
  • Sigma-Aldrich
  • Levocarnitine Pharmaceutical Secondary Standard; Certified Reference Material
  • 1g
  • $ 39.30
  • Sigma-Aldrich
  • L-Carnitine for synthesis. CAS 541-15-1, pH 6.5 - 8.5 (50 g/l, H O)., for synthesis
  • 8400920025
  • $ 97.70
Total 396 raw suppliers
Chemical Property of Levocarnitine Edit
Chemical Property:
  • Appearance/Colour:white crystalline powder 
  • Melting Point:197-212 °C(lit.) 
  • Refractive Index:-32 ° (C=1, H2O) 
  • Boiling Point:287.5°C (rough estimate) 
  • PKA:3.80(at 25℃) 
  • PSA:60.36000 
  • Density:0.64 g/cm3 
  • LogP:-1.80650 
  • Storage Temp.:2-8°C 
  • Solubility.:H2O: 0.1 g/mL at 20 °C, clear, colorless 
  • Water Solubility.:2500 g/L (20 ºC) 
  • XLogP3:-0.2
  • Hydrogen Bond Donor Count:1
  • Hydrogen Bond Acceptor Count:3
  • Rotatable Bond Count:3
  • Exact Mass:161.10519334
  • Heavy Atom Count:11
  • Complexity:134
Purity/Quality:

99%,98%, *data from raw suppliers

D-Carnitine *data from reagent suppliers

Safty Information:
  • Pictogram(s): IrritantXi 
  • Hazard Codes:Xi 
  • Statements: 36/37/38 
  • Safety Statements: 26-36-37/39 
MSDS Files:

SDS file from LookChem

Useful:
  • Chemical Classes:Biological Agents -> Amino Acids and Derivatives
  • Canonical SMILES:C[N+](C)(C)CC(CC(=O)[O-])O
  • Isomeric SMILES:C[N+](C)(C)C[C@@H](CC(=O)[O-])O
  • Recent ClinicalTrials:Levocarnitine To Protect the Liver From Chemotherapy for Leukemia or Lymphoma
  • Recent EU Clinical Trials:Carnitine supplementation as a therapy to improve insulin sensitivity in Type 2 diabetic patients with low carnitine status
  • Recent NIPH Clinical Trials:The effects of electrical stimulation for lower limbs to maintenance hemodialysis patients with frailty receiving carnitine: A pilot study
  • Role in Cellular Energy Metabolism Levocarnitine is an essential component in cellular energy metabolism, contributing to the transport of fatty acids into the mitochondria for energy production.
  • Treatment for Valproic Acid Overdose Levocarnitine, the active isomer of carnitine, has been utilized in the treatment of valproic acid overdose, including cases resulting from both overdose and regular dosages of valproic acid.
  • Bioavailability and Distribution While a single dose of levocarnitine does not persist in the system for an extended period, chronic intravenous administration in hemodialysis patients can lead to significant uptake into tissues, with muscle carnitine levels increasing by up to 200%.
  • Effectiveness in Renal Anemia Studies have shown that levocarnitine treatment can ameliorate renal anemia and reduce the requirements for erythropoiesis-stimulating agents (ESAs) in hemodialysis patients. Multiple studies support the efficacy of levocarnitine in treating renal anemia.
  • Beneficial Effects on Dyslipidemia Levocarnitine supplementation may benefit dialysis patients with dyslipidemia by enhancing the transport of free fatty acids into mitochondria and reducing their availability for triglyceride synthesis.
  • Restoration of Carnitine Levels Levocarnitine supplementation has been found to restore normal plasma carnitine levels and alleviate symptomatic deficiencies with good tolerability. In hemodialysis patients, it increases plasma carnitine concentrations and improves fatigue as assessed by patients.
Technology Process of Levocarnitine

There total 94 articles about Levocarnitine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
With hydrogenchloride; sodium hydroxide; In water; at 15 ℃; for 0.13h; under 4500.45 Torr; Temperature; Pressure;
Guidance literature:
With sodium hydroxide; In water; at 0 - 20 ℃; for 2h; Product distribution / selectivity;
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