Levocarnitine

Base Information Edit

Chemical Name:Levocarnitine
CAS No.:541-15-1
Deprecated CAS:7634-98-2
Molecular Formula:C7H15NO3
Molecular Weight:161.201
Hs Code.: Oral rats LD50: 14,000 mg/Kg
European Community (EC) Number:208-768-0
NSC Number:759132,741806
UNII:0G389FZZ9M
DSSTox Substance ID:DTXSID4023208
Wikipedia:Carnitine
Wikidata:Q20735709
NCI Thesaurus Code:C26657
RXCUI:42955
Metabolomics Workbench ID:42914
ChEMBL ID:CHEMBL1149
Mol file:541-15-1.mol

Synonyms:Bicarnesine;Carnitine;L Carnitine;L-Carnitine;Levocarnitine;Vitamin BT

Suppliers and Price of Levocarnitine

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
D-Carnitine
2.5mg
$ 446.00

TRC
L-Carnitine-13CChloride
1mg
$ 155.00

TCI Chemical
L-Carnitine >98.0%(T)
5g
$ 46.00

TCI Chemical
L-Carnitine >98.0%(T)
25g
$ 136.00

SynQuest Laboratories
(3R)-(-)-3-Hydroxy-4-(trimethylammonio)butanoate 99.0%
250 g
$ 132.00

SynQuest Laboratories
(3R)-(-)-3-Hydroxy-4-(trimethylammonio)butanoate 99.0%
25 g
$ 21.00

SynQuest Laboratories
(3R)-(-)-3-Hydroxy-4-(trimethylammonio)butanoate 99.0%
100 g
$ 55.00

Sigma-Aldrich
L-Carnitine inner salt synthetic, ≥98%
1g
$ 40.70

Sigma-Aldrich
Levocarnitine Pharmaceutical Secondary Standard; Certified Reference Material
1g
$ 39.30

Sigma-Aldrich
L-Carnitine for synthesis. CAS 541-15-1, pH 6.5 - 8.5 (50 g/l, H O)., for synthesis
8400920025
$ 97.70

Total 395 raw suppliers

Chemical Property of Levocarnitine Edit

Chemical Property:

Appearance/Colour:white crystalline powder
Melting Point:197-212 °C(lit.)
Refractive Index:-32 ° (C=1, H2O)
Boiling Point:287.5°C (rough estimate)
PKA:3.80(at 25℃)
PSA：60.36000
Density:0.64 g/cm3
LogP:-1.80650
Storage Temp.:2-8°C
Solubility.:H2O: 0.1 g/mL at 20 °C, clear, colorless
Water Solubility.:2500 g/L (20 ºC)
XLogP3:-0.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:161.10519334
Heavy Atom Count:11
Complexity:134

Purity/Quality:

99%,98%, ^*data from raw suppliers

D-Carnitine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36-37/39

MSDS Files:: SDS file from LookChem

Useful:

Chemical Classes:Biological Agents -> Amino Acids and Derivatives
Canonical SMILES:C[N+](C)(C)CC(CC(=O)[O-])O
Isomeric SMILES:C[N+](C)(C)C[C@@H](CC(=O)[O-])O
Recent ClinicalTrials:Levocarnitine To Protect the Liver From Chemotherapy for Leukemia or Lymphoma
Recent EU Clinical Trials:Carnitine supplementation as a therapy to improve insulin sensitivity in Type 2 diabetic patients with low carnitine status
Recent NIPH Clinical Trials:The effects of electrical stimulation for lower limbs to maintenance hemodialysis patients with frailty receiving carnitine: A pilot study
Role in Cellular Energy Metabolism Levocarnitine is an essential component in cellular energy metabolism, contributing to the transport of fatty acids into the mitochondria for energy production.
Treatment for Valproic Acid Overdose Levocarnitine, the active isomer of carnitine, has been utilized in the treatment of valproic acid overdose, including cases resulting from both overdose and regular dosages of valproic acid.
Bioavailability and Distribution While a single dose of levocarnitine does not persist in the system for an extended period, chronic intravenous administration in hemodialysis patients can lead to significant uptake into tissues, with muscle carnitine levels increasing by up to 200%.
Effectiveness in Renal Anemia Studies have shown that levocarnitine treatment can ameliorate renal anemia and reduce the requirements for erythropoiesis-stimulating agents (ESAs) in hemodialysis patients. Multiple studies support the efficacy of levocarnitine in treating renal anemia.
Beneficial Effects on Dyslipidemia Levocarnitine supplementation may benefit dialysis patients with dyslipidemia by enhancing the transport of free fatty acids into mitochondria and reducing their availability for triglyceride synthesis.
Restoration of Carnitine Levels Levocarnitine supplementation has been found to restore normal plasma carnitine levels and alleviate symptomatic deficiencies with good tolerability. In hemodialysis patients, it increases plasma carnitine concentrations and improves fatigue as assessed by patients.

Technology Process of Levocarnitine

There total 94 articles about Levocarnitine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.6%