methyl [2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]-3-oxo-pyridazin-4-yl]carbonate

Base Information

Chemical Name:methyl [2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]-3-oxo-pyridazin-4-yl]carbonate
CAS No.:1429872-85-4
Molecular Formula:C₁₅H₁₃F₃N₂O₆S
Molecular Weight:406.339
Hs Code.:

Synonyms:methyl [2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]-3-oxo-pyridazin-4-yl]carbonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl [2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]-3-oxo-pyridazin-4-yl]carbonate

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Technology Process of methyl [2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]-3-oxo-pyridazin-4-yl]carbonate

There total 7 articles about methyl [2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]-3-oxo-pyridazin-4-yl]carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.87%

: 1429870-80-3
4-hydroxy-2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]pyridazin-3-one

: 79-22-1
methyl chloroformate

: 1429872-85-4
methyl [2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]-3-oxo-pyridazin-4-yl]carbonate

Guidance literature:: With triethylamine; In toluene; at 20 ℃;

Reference yield:

: 77541-59-4
5-chloro-4-methoxy-2-methyl-3(2H)-pyridazinone

: 1429872-85-4
methyl [2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]-3-oxo-pyridazin-4-yl]carbonate

Guidance literature:: Multi-step reaction with 5 steps

1: tricyclohexylphosphine; potassium acetate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 0.25 h / 150 °C / Microwave irradiation

2: cesium fluoride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 0.25 h / 160 °C / Microwave irradiation

3: dihydrogen peroxide; acetic acid / water / 55 °C

4: morpholine / 3 h / 100 °C

5: triethylamine / toluene / 20 °C

With morpholine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; dihydrogen peroxide; potassium acetate; acetic acid; triethylamine; cesium fluoride; tricyclohexylphosphine; In 1,4-dioxane; 1,2-dimethoxyethane; water; toluene;

Reference yield:

: 933-76-6
4,5-dichloro-2-methyl-3(2H)-pyridazinone

: 1429872-85-4
methyl [2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]-3-oxo-pyridazin-4-yl]carbonate

Guidance literature:: Multi-step reaction with 6 steps

1: 1,4-dioxane / 1 h / 20 °C

2: tricyclohexylphosphine; potassium acetate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 0.25 h / 150 °C / Microwave irradiation

3: cesium fluoride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 0.25 h / 160 °C / Microwave irradiation

4: dihydrogen peroxide; acetic acid / water / 55 °C

5: morpholine / 3 h / 100 °C

6: triethylamine / toluene / 20 °C

With morpholine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; dihydrogen peroxide; potassium acetate; acetic acid; triethylamine; cesium fluoride; tricyclohexylphosphine; In 1,4-dioxane; 1,2-dimethoxyethane; water; toluene;