4-hydroxy-2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]pyridazin-3-one

Base Information

Chemical Name:4-hydroxy-2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]pyridazin-3-one
CAS No.:1429870-80-3
Molecular Formula:C₁₃H₁₁F₃N₂O₄S
Molecular Weight:348.303
Hs Code.:

Synonyms:4-hydroxy-2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]pyridazin-3-one

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Chemical Property of 4-hydroxy-2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]pyridazin-3-one

Chemical Property:

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Technology Process of 4-hydroxy-2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]pyridazin-3-one

There total 6 articles about 4-hydroxy-2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]pyridazin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1429874-17-8
4-methoxy-2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]pyridazin-3-one

: 1429870-80-3
4-hydroxy-2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]pyridazin-3-one

Guidance literature:: With morpholine; at 100 ℃; for 3h;

Reference yield:

: 77541-59-4
5-chloro-4-methoxy-2-methyl-3(2H)-pyridazinone

: 1429870-80-3
4-hydroxy-2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]pyridazin-3-one

Guidance literature:: Multi-step reaction with 4 steps

1: tricyclohexylphosphine; potassium acetate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 0.25 h / 150 °C / Microwave irradiation

2: cesium fluoride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 0.25 h / 160 °C / Microwave irradiation

3: dihydrogen peroxide; acetic acid / water / 55 °C

4: morpholine / 3 h / 100 °C

With morpholine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; dihydrogen peroxide; potassium acetate; acetic acid; cesium fluoride; tricyclohexylphosphine; In 1,4-dioxane; 1,2-dimethoxyethane; water;

Reference yield:

: 933-76-6
4,5-dichloro-2-methyl-3(2H)-pyridazinone

: 1429870-80-3
4-hydroxy-2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]pyridazin-3-one

Guidance literature:: Multi-step reaction with 5 steps

1: 1,4-dioxane / 1 h / 20 °C

2: tricyclohexylphosphine; potassium acetate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 0.25 h / 150 °C / Microwave irradiation

3: cesium fluoride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 0.25 h / 160 °C / Microwave irradiation

4: dihydrogen peroxide; acetic acid / water / 55 °C

5: morpholine / 3 h / 100 °C

With morpholine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; dihydrogen peroxide; potassium acetate; acetic acid; cesium fluoride; tricyclohexylphosphine; In 1,4-dioxane; 1,2-dimethoxyethane; water;