diethyl 2-(1-amino-3-phenylpropylidene)malonate

Base Information

Chemical Name:diethyl 2-(1-amino-3-phenylpropylidene)malonate
CAS No.:1353674-40-4
Molecular Formula:C₁₆H₂₁NO₄
Molecular Weight:291.347
Hs Code.:

Synonyms:diethyl 2-(1-amino-3-phenylpropylidene)malonate

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Chemical Property of diethyl 2-(1-amino-3-phenylpropylidene)malonate

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Technology Process of diethyl 2-(1-amino-3-phenylpropylidene)malonate

There total 4 articles about diethyl 2-(1-amino-3-phenylpropylidene)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 65680-20-8
phenylpropionic acid thioamide

: 685-87-0
Diethyl 2-bromomalonate

: 1353674-40-4
diethyl 2-(1-amino-3-phenylpropylidene)malonate

Guidance literature:: With sodium carbonate; In dichloromethane; for 2.5h; Sonication;
DOI:10.1039/c2ra22033d

Reference yield: 85.0%

: 5256-74-6
1,3-diethyl 2-diazopropanedioate

: 65680-20-8
phenylpropionic acid thioamide

: 1353674-40-4
diethyl 2-(1-amino-3-phenylpropylidene)malonate

Guidance literature:: With Grubbs catalyst first generation; In benzene; at 90 ℃; for 12h; Reagent/catalyst; Temperature; Time; Inert atmosphere; Sealed tube;
DOI:10.1021/jo5011312

Reference yield:

: 105-53-3
diethyl malonate

: 1353674-40-4
diethyl 2-(1-amino-3-phenylpropylidene)malonate

Guidance literature:: Multi-step reaction with 2 steps

1: 4-toluenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0 - 20 °C

2: Grubbs catalyst first generation / benzene / 26 h / 120 °C / Sealed tube; Inert atmosphere

With Grubbs catalyst first generation; 4-toluenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; benzene;
DOI:10.1021/ol202812d