65680-20-8

Upstream product

• 102-93-2 3-phenylpropionamide 
• 645-59-0 dihydrocinnamonitrile 
• 298-06-6 O,O-Diethyl hydrogen phosphorodithioate 
• 64-17-5 ethanol 
• 7783-06-4 hydrogen sulfide 
• 141-52-6 sodium ethanolate 
• 501-52-0 3-Phenylpropionic acid 
• 19172-47-5 Lawessons reagent 

Downstream Products

• 93948-20-0 bis-(3-phenyl-propyl)-amine 
• 645-59-0 dihydrocinnamonitrile 
• 2038-57-5 3-Phenylpropan-1-amine 
• 28077-45-4 2-methoxy-5-(2-benzyl thiazol-4-yl)-benzoic acid 
• 1353674-40-4 diethyl 2-(1-amino-3-phenylpropylidene)malonate 
• 1628755-49-6 C₁₈H₁₉ClN₂S 
• 1611471-50-1 5-(2-methylpropyl)-4-morpholin-4-yl-2-phenethylthieno[2,3-d]pyrimidine 
• 1611471-53-4 5-(2-methylpropyl)-2-phenethyl-4-(4-phenylpiperazin-1-yl)thieno[2,3-d]pyrimidine 
• 1611471-33-0 5-(2-methylpropyl)-2-phenethyl-3H-thieno[2,3-d]pyrimidin-4-one 
• 1421276-95-0 (E)-ethyl 2-acetyl-3-amino-5-phenylpent-2-enoate 
• 1621003-96-0 2-phenethyl-4-phenyl-4,5-dihydrothiazol-4-ol 
• 1621003-89-1 2-(1-amino-3-phenylpropylidene)-5,5-dimethylcyclohexane-1,3-dione 
• 65346-64-7 2-phenethyl-thiazole-4-carboxylic acid 
• 161772-81-2 2-(2'-phenylethyl)-4-carbethoxythiazole 

Relevant academic research and scientific papers

Metal-free dehydrosulfurization of thioamides to nitriles under visible light

A visible light-mediated, metal-free dehydrosulfurization reaction of thioamides to nitriles is described. This reaction features high yields, mild reaction conditions, and the use of a cheap organic dye as the photoredox catalyst and air as the oxidant.

Structure-activity relationship study of thiazolyl-hydroxamate derivatives as selective histone deacetylase 6 inhibitors

Several human diseases are associated with aberrant epigenetic pathways mediated by histone deacetylases (HDACs), especially HDAC6, a class IIb HDACs, which has emerged as an attractive target for neurodegenerative and autoimmune disease therapeutics. In a previous study, we developed the novel HDAC6-selective inhibitor 9a ((E)-N-hydroxy-4-(2-styrylthiazol-4-yl)butanamide) and showed that it has anti-sepsis activity in vivo. In this study, we conducted structure-activity relationship (SAR) studies to optimize the activity and selectivity of HDAC6, synthesizing its derivatives with various aliphatic linker sizes and cap structures. We identified 6u ((E)-N-hydroxy-3-(2-(4-fluorostyryl)thiazol-4-yl)propanamide), which has nanomolar inhibition activity and a 126-fold selectivity for HDAC6 over HDAC1. Through the docking analyses of 6u against HDAC subtypes, we revealed the importance of the optimal aliphatic linker size, as well as the electronic substituent effect and rigidity of the aryl cap group. Thus, we suggest a new rationale for the design of HDAC6-selective inhibitors.

AUTOTAXIN INHIBITORS

The present invention relates to compounds of formula (I): wherein R1, R2, R3, R4a, R4b, R4C, R4d, L, A, Q, W and HET are each as defined herein. The compounds of the present inv

Microwave-assisted synthesis of potent PDE7 inhibitors containing a thienopyrimidin-4-amine scaffold

A series of novel thienopyrimidin-4-amines have been synthesized and evaluated as phosphodiesterase (PDE) inhibitors. A rationale for the observed selectivity against PDE7 has been obtained from molecular modelling studies on the most active compounds. This journal is the Partner Organisations 2014.

Ruthenium catalyzed synthesis of enaminones

The Grubbs first-generation catalyst has been found to be an effective catalyst for the synthesis of enaminones by coupling thioamides with α-diazodicarbonyl compounds. The reaction is successful in converting primary, secondary, and tertiary thioamides into their corresponding enaminones. The reaction is also suitable for the synthesis of chiral enaminones.

Substituted thiazoles for the treatment of inflammation

A class of substituted thiazolyl compounds is described for use in treating inflammation disorders. Compounds are defined by Formula II STR1 wherein R1 is selected from hydrido, alkyl, haloalkyl, cyanoalkyl, alkylamino, aralkyl, arylamino, heteroarylsulfonylalkyl, heteroarylsulfonylhaloalkyl, aralkylamino, aryloxyalkyl, alkoxycarbonyl, aryl optionally substituted at a substitutable position with one or more radicals selected from halo and alkoxy, and heterocyclic optionally substituted at a substitutable position with one or more radicals selected from halo and alkyl; wherein R4 is selected from alkyl and amino; and wherein R5 is selected from aryl and heteroaryl; wherein R5 is optionally substituted at a substitutable position with one or more radicals selected from halo, alkyl and alkoxy; provided R5 is not phenyl at position 4 when R1 is α,α-bis(trifluoromethyl)methanol and R4 is methyl; or a pharmaceutically-acceptable salt thereof.

THE REACTION OF NITRILES WITH O,O-DIALKYL-DITHIOPHOSPHORIC ACIDS

Nitriles react with dialkyldithiophosphoric acids 2a-c to give a mixture of corresponding thioamides and O,O-dialkyl-N-thioacetyl-phosphoroamidothioates 3a-e.The structure of compounds 3 are elucidated chemically and from electronic spectra.The yield of thioamides are improved from the reaction of nitriles with compound 2b in presence of water.Mechanistic consideration on the formation of the products are discussed.

STUDIES ON ORGANOPHOSPHORUS COMPOUNDS PART 55 THE TRANSFORMATION OF NITRILES TO THIOAMIDES WITH O,O-DIALKYLDITHIOPHOSPHORIC ACID

The reaction between nitriles and O,O-dialkyldithiophosphoric acid (2) under anhydrous conditions produces O,O-diethyl-N-thiobenzoylamidophosphate (5), contrary to literature.When water is present the same reaction gives the corresponding thioamides in reasonable to good yields.Mechanistic considerations and spectral data are presented for the products.