N,N'-Bis(4-phenoxyphenyl)urea

Base Information

• Chemical Name: N,N'-Bis(4-phenoxyphenyl)urea
• CAS No.: 105482-59-5
• Molecular Formula: C₂₅H₂₀N₂O₃
• Molecular Weight: 396.445
• DSSTox Substance ID: DTXSID201308297
• Nikkaji Number: J2.730.882A
• Mol file: 105482-59-5.mol

Synonyms:Urea, N,N'-bis(4-phenoxyphenyl)-;105482-59-5;N,N'-Bis(4-phenoxyphenyl)urea;DTXSID201308297;AKOS003537782

Chemical Property of N,N'-Bis(4-phenoxyphenyl)urea

Chemical Property:

• XLogP3: 6.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 396.14739250
• Heavy Atom Count: 30
• Complexity: 457

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC=C(C=C3)OC4=CC=CC=C4

Technology Process of N,N'-Bis(4-phenoxyphenyl)urea

There total 7 articles about N,N'-Bis(4-phenoxyphenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

carbon dioxide (124-38-9,18923-20-1) + C15H19NOSi → N,N'-bis(4-phenoxyphenyl)urea (105482-59-5)

Guidance literature:

With pyridine; C₁₄H₃₄Cl₂InNO₂Si₂; In toluene; at 110 ℃; for 12h; under 2280.15 Torr;

DOI:10.1002/anie.201708921

Reference yield: 85.0%

carbon monoxide (201230-82-2) + 4-phenoxyanilin (139-59-3) → N,N'-bis(4-phenoxyphenyl)urea (105482-59-5)

Guidance literature:

With Co₂Rh₂; oxygen; In tetrahydrofuran; at 100 ℃; for 15h; under 3800.26 Torr; Autoclave;

DOI:10.1002/adsc.200900106

Reference yield: 45.0%

carbon monoxide (201230-82-2) + 4-chloro-3-trifluoromethyl-aniline (320-51-4) + 4-phenoxyanilin (139-59-3) → 1-[4-chloro-3-(trifluoromethyl)phenyl]-3-(4-phenoxyphenyl)urea + N,N'-bis(4-phenoxyphenyl)urea (105482-59-5)

Guidance literature:

With dmap; tungsten hexacarbonyl; iodine; In dichloromethane; at 40 ℃; for 20h; under 60804.1 Torr;

DOI:10.1002/ejoc.201100657

upstream raw materials:

carbon monoxide

4-phenoxyanilin

4-chloro-aniline

4-chloro-3-trifluoromethyl-aniline