(S)-4-Benzyloxy-1-((2R,6R)-6-ethyl-5-methyl-3,6-dihydro-2H-pyran-2-yl)-3-methyl-butan-1-one

Base Information

Chemical Name:(S)-4-Benzyloxy-1-((2R,6R)-6-ethyl-5-methyl-3,6-dihydro-2H-pyran-2-yl)-3-methyl-butan-1-one
CAS No.:406684-19-3
Molecular Formula:C₂₀H₂₈O₃
Molecular Weight:316.441
Hs Code.:

Synonyms:(S)-4-Benzyloxy-1-((2R,6R)-6-ethyl-5-methyl-3,6-dihydro-2H-pyran-2-yl)-3-methyl-butan-1-one

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Chemical Property of (S)-4-Benzyloxy-1-((2R,6R)-6-ethyl-5-methyl-3,6-dihydro-2H-pyran-2-yl)-3-methyl-butan-1-one

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Technology Process of (S)-4-Benzyloxy-1-((2R,6R)-6-ethyl-5-methyl-3,6-dihydro-2H-pyran-2-yl)-3-methyl-butan-1-one

There total 9 articles about (S)-4-Benzyloxy-1-((2R,6R)-6-ethyl-5-methyl-3,6-dihydro-2H-pyran-2-yl)-3-methyl-butan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 90344-49-3
(2R)-3-iodo-2-methylpropyl benzyl ether

: C₁₁H₁₉NO₃

: 406684-19-3
(S)-4-Benzyloxy-1-((2R,6R)-6-ethyl-5-methyl-3,6-dihydro-2H-pyran-2-yl)-3-methyl-butan-1-one

Guidance literature:: (2R)-3-iodo-2-methylpropyl benzyl ether; With tert.-butyl lithium; In diethyl ether; pentane; at -100 - -78 ℃; for 0.166667h;

C₁₁H₁₉NO₃; In diethyl ether; at -100 - -78 ℃; for 0.25h;
DOI:10.1002/chem.202100975

Reference yield: 83.0%

: C₁₁H₁₅BrMgO

: 406684-17-1
(S)-4-Benzyl-3-((2R,6R)-6-ethyl-5-methyl-3,6-dihydro-2H-pyran-2-carbonyl)-oxazolidin-2-one

: 406684-19-3
(S)-4-Benzyloxy-1-((2R,6R)-6-ethyl-5-methyl-3,6-dihydro-2H-pyran-2-yl)-3-methyl-butan-1-one

Guidance literature:: (S)-4-Benzyl-3-((2R,6R)-6-ethyl-5-methyl-3,6-dihydro-2H-pyran-2-carbonyl)-oxazolidin-2-one; With trimethylaluminum; N,O-dimethylhydroxylamine*hydrochloride; In tetrahydrofuran; at 0 ℃; for 3h;

C₁₁H₁₅BrMgO; In tetrahydrofuran; at 40 ℃; for 8h;
DOI:10.1002/1521-3773(20020104)41:1<176::AID-ANIE176>3.0.CO;2-#

Reference yield:

: 125637-07-2,2088-07-5
(R)-3-hydroxy-2-methylpent-1-ene

: 406684-19-3
(S)-4-Benzyloxy-1-((2R,6R)-6-ethyl-5-methyl-3,6-dihydro-2H-pyran-2-yl)-3-methyl-butan-1-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: 100 percent / NaH / 8 h / 20 °C

2.1: (CH₃)3COCl; N(C₂H₅)3 / diethyl ether / -78 - 0 °C

2.2: 72 percent / tetrahydrofuran; diethyl ether / 8 h / -78 °C

3.1: 72 percent / ((CH₃)3Si)2NNa / tetrahydrofuran / 5 h / -78 - -45 °C

4.1: PhCl₂(CHPh)(P(C₆H₁₁)3)2 / CH₂Cl₂ / 3 h / Heating

4.2: 98 percent / Pb(OCOCH₃)4 / CH₂Cl₂

5.1: CH₃NHOCH₃*HCl; (CH₃)3Al / tetrahydrofuran / 3 h / 0 °C

5.2: 83 percent / tetrahydrofuran / 8 h / 40 °C

With tert-butylhypochlorite; PhCl₂(CHPh)(P(C₆H₁₁)3)2; trimethylaluminum; sodium hexamethyldisilazane; N,O-dimethylhydroxylamine*hydrochloride; sodium hydride; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1002/1521-3773(20020104)41:1<176::AID-ANIE176>3.0.CO;2-#