(S)-4-Benzyl-3-((2R,6R)-6-ethyl-5-methyl-3,6-dihydro-2H-pyran-2-carbonyl)-oxazolidin-2-one

Base Information

Chemical Name:(S)-4-Benzyl-3-((2R,6R)-6-ethyl-5-methyl-3,6-dihydro-2H-pyran-2-carbonyl)-oxazolidin-2-one
CAS No.:406684-17-1
Molecular Formula:C₁₉H₂₃NO₄
Molecular Weight:329.396
Hs Code.:

Synonyms:(S)-4-Benzyl-3-((2R,6R)-6-ethyl-5-methyl-3,6-dihydro-2H-pyran-2-carbonyl)-oxazolidin-2-one

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Chemical Property of (S)-4-Benzyl-3-((2R,6R)-6-ethyl-5-methyl-3,6-dihydro-2H-pyran-2-carbonyl)-oxazolidin-2-one

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Technology Process of (S)-4-Benzyl-3-((2R,6R)-6-ethyl-5-methyl-3,6-dihydro-2H-pyran-2-carbonyl)-oxazolidin-2-one

There total 4 articles about (S)-4-Benzyl-3-((2R,6R)-6-ethyl-5-methyl-3,6-dihydro-2H-pyran-2-carbonyl)-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 406684-16-0
(S)-4-Benzyl-3-[(R)-2-((R)-1-ethyl-2-methyl-allyloxy)-pent-4-enoyl]-oxazolidin-2-one

: 406684-17-1
(S)-4-Benzyl-3-((2R,6R)-6-ethyl-5-methyl-3,6-dihydro-2H-pyran-2-carbonyl)-oxazolidin-2-one

Guidance literature:: (S)-4-Benzyl-3-[(R)-2-((R)-1-ethyl-2-methyl-allyloxy)-pent-4-enoyl]-oxazolidin-2-one; With PhCl₂(CHPh)(P(C₆H₁₁)3)2; In dichloromethane; for 3h; Heating;

With lead(IV) acetate; In dichloromethane;
DOI:10.1002/1521-3773(20020104)41:1<176::AID-ANIE176>3.0.CO;2-#

Reference yield:

: 125637-07-2,2088-07-5
(R)-3-hydroxy-2-methylpent-1-ene

: 406684-17-1
(S)-4-Benzyl-3-((2R,6R)-6-ethyl-5-methyl-3,6-dihydro-2H-pyran-2-carbonyl)-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 100 percent / NaH / 8 h / 20 °C

2.1: (CH₃)3COCl; N(C₂H₅)3 / diethyl ether / -78 - 0 °C

2.2: 72 percent / tetrahydrofuran; diethyl ether / 8 h / -78 °C

3.1: 72 percent / ((CH₃)3Si)2NNa / tetrahydrofuran / 5 h / -78 - -45 °C

4.1: PhCl₂(CHPh)(P(C₆H₁₁)3)2 / CH₂Cl₂ / 3 h / Heating

4.2: 98 percent / Pb(OCOCH₃)4 / CH₂Cl₂

With tert-butylhypochlorite; PhCl₂(CHPh)(P(C₆H₁₁)3)2; sodium hexamethyldisilazane; sodium hydride; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1002/1521-3773(20020104)41:1<176::AID-ANIE176>3.0.CO;2-#

Reference yield:

: 406684-14-8
((R)-1-Ethyl-2-methyl-allyloxy)-acetic acid

: 406684-17-1
(S)-4-Benzyl-3-((2R,6R)-6-ethyl-5-methyl-3,6-dihydro-2H-pyran-2-carbonyl)-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: (CH₃)3COCl; N(C₂H₅)3 / diethyl ether / -78 - 0 °C

1.2: 72 percent / tetrahydrofuran; diethyl ether / 8 h / -78 °C

2.1: 72 percent / ((CH₃)3Si)2NNa / tetrahydrofuran / 5 h / -78 - -45 °C

3.1: PhCl₂(CHPh)(P(C₆H₁₁)3)2 / CH₂Cl₂ / 3 h / Heating

3.2: 98 percent / Pb(OCOCH₃)4 / CH₂Cl₂

With tert-butylhypochlorite; PhCl₂(CHPh)(P(C₆H₁₁)3)2; sodium hexamethyldisilazane; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1002/1521-3773(20020104)41:1<176::AID-ANIE176>3.0.CO;2-#