(3S)-3-(3-chloro-5-(4-(fluoromethyl)tetrahydro-2H-pyran-4-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoic acid

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Chemical Name:(3S)-3-(3-chloro-5-(4-(fluoromethyl)tetrahydro-2H-pyran-4-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoic acid
CAS No.:1541197-29-8
Molecular Formula:C₂₈H₃₃ClFN₅O₇
Molecular Weight:606.051
Hs Code.:

(3S)-3-(3-chloro-5-(4-(fluoromethyl)tetrahydro-2H-pyran-4-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoic acid

Synonyms:(3S)-3-(3-chloro-5-(4-(fluoromethyl)tetrahydro-2H-pyran-4-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoic acid

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Chemical Property of (3S)-3-(3-chloro-5-(4-(fluoromethyl)tetrahydro-2H-pyran-4-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoic acid

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Technology Process of (3S)-3-(3-chloro-5-(4-(fluoromethyl)tetrahydro-2H-pyran-4-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoic acid

There total 14 articles about (3S)-3-(3-chloro-5-(4-(fluoromethyl)tetrahydro-2H-pyran-4-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1541199-21-6
(3S)-ethyl 3-(3-chloro-5-(4-(fluoromethyl)tetrahydro-2H-pyran-4-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoate

: 1541197-29-8
(3S)-3-(3-chloro-5-(4-(fluoromethyl)tetrahydro-2H-pyran-4-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoic acid

Guidance literature:: With lithium hydroxide monohydrate; In water; acetonitrile; at 20 ℃; for 4h;

Reference yield:

: 230642-94-1
2-(3-chloro-5-formylphenyl)-2-methylpropanenitrile

: 1541197-29-8
(3S)-3-(3-chloro-5-(4-(fluoromethyl)tetrahydro-2H-pyran-4-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: n-butyllithium; N-cyclohexyl-cyclohexanamine / hexane; toluene / 0.08 h / 0 - 25 °C / Inert atmosphere

1.2: 1 h / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 25 °C

3.1: diethylamino-sulfur trifluoride / dichloromethane / 1 h / -60 °C / Inert atmosphere

4.1: toluene-4-sulfonic acid / acetone / 20 °C / Inert atmosphere

5.1: ammonium acetate / ethanol / 7 h / Reflux

6.1: 2,6-dimethylpyridine / dichloromethane / 10 h / 20 °C

7.1: Resolution of racemate

8.1: hydrogenchloride / ethyl acetate / 1 h

9.1: benzotriazol-1-ol / N,N-dimethyl-formamide; dichloromethane / 0.17 h / 20 °C / Inert atmosphere

9.2: 20 °C / Inert atmosphere

10.1: lithium hydroxide monohydrate / acetonitrile; water / 4 h / 20 °C

With 2,6-dimethylpyridine; hydrogenchloride; lithium aluminium tetrahydride; n-butyllithium; lithium hydroxide monohydrate; diethylamino-sulfur trifluoride; ammonium acetate; benzotriazol-1-ol; toluene-4-sulfonic acid; N-cyclohexyl-cyclohexanamine; In tetrahydrofuran; ethanol; hexane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone; toluene; acetonitrile;

Reference yield:

: 1541198-15-5
C₁₃H₁₄ClFO₂

: 1541197-29-8
(3S)-3-(3-chloro-5-(4-(fluoromethyl)tetrahydro-2H-pyran-4-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: ammonium acetate / ethanol / 7 h / Reflux

2.1: 2,6-dimethylpyridine / dichloromethane / 10 h / 20 °C

3.1: Resolution of racemate

4.1: hydrogenchloride / ethyl acetate / 1 h

5.1: benzotriazol-1-ol / N,N-dimethyl-formamide; dichloromethane / 0.17 h / 20 °C / Inert atmosphere

5.2: 20 °C / Inert atmosphere

6.1: lithium hydroxide monohydrate / acetonitrile; water / 4 h / 20 °C

With 2,6-dimethylpyridine; hydrogenchloride; lithium hydroxide monohydrate; ammonium acetate; benzotriazol-1-ol; In ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;