(3S)-ethyl 3-(3-chloro-5-(4-(fluoromethyl)tetrahydro-2H-pyran-4-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoate

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Chemical Name:(3S)-ethyl 3-(3-chloro-5-(4-(fluoromethyl)tetrahydro-2H-pyran-4-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoate
CAS No.:1541199-21-6
Molecular Formula:C₃₀H₃₇ClFN₅O₇
Molecular Weight:634.104
Hs Code.:

(3S)-ethyl 3-(3-chloro-5-(4-(fluoromethyl)tetrahydro-2H-pyran-4-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoate

Synonyms:(3S)-ethyl 3-(3-chloro-5-(4-(fluoromethyl)tetrahydro-2H-pyran-4-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoate

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Chemical Property of (3S)-ethyl 3-(3-chloro-5-(4-(fluoromethyl)tetrahydro-2H-pyran-4-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoate

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Technology Process of (3S)-ethyl 3-(3-chloro-5-(4-(fluoromethyl)tetrahydro-2H-pyran-4-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoate

There total 13 articles about (3S)-ethyl 3-(3-chloro-5-(4-(fluoromethyl)tetrahydro-2H-pyran-4-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 290826-72-1
2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetic acid

: 1541198-13-3
(S)-ethyl 3-amino-3-(3-chloro-5-(4-(fluoromethyl)tetrahydro-2H-pyran-4-yl)phenyl)propanoate hydrochloride

: 1541199-21-6
(3S)-ethyl 3-(3-chloro-5-(4-(fluoromethyl)tetrahydro-2H-pyran-4-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoate

Guidance literature:: 2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetic acid; (S)-ethyl 3-amino-3-(3-chloro-5-(4-(fluoromethyl)tetrahydro-2H-pyran-4-yl)phenyl)propanoate hydrochloride; With benzotriazol-1-ol; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 0.166667h; Inert atmosphere;

With diisopropyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

Reference yield:

: 230642-94-1
2-(3-chloro-5-formylphenyl)-2-methylpropanenitrile

: 1541199-21-6
(3S)-ethyl 3-(3-chloro-5-(4-(fluoromethyl)tetrahydro-2H-pyran-4-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoate

Guidance literature:: Multi-step reaction with 9 steps

1.1: n-butyllithium; N-cyclohexyl-cyclohexanamine / hexane; toluene / 0.08 h / 0 - 25 °C / Inert atmosphere

1.2: 1 h / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 25 °C

3.1: diethylamino-sulfur trifluoride / dichloromethane / 1 h / -60 °C / Inert atmosphere

4.1: toluene-4-sulfonic acid / acetone / 20 °C / Inert atmosphere

5.1: ammonium acetate / ethanol / 7 h / Reflux

6.1: 2,6-dimethylpyridine / dichloromethane / 10 h / 20 °C

7.1: Resolution of racemate

8.1: hydrogenchloride / ethyl acetate / 1 h

9.1: benzotriazol-1-ol / N,N-dimethyl-formamide; dichloromethane / 0.17 h / 20 °C / Inert atmosphere

9.2: 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; hydrogenchloride; lithium aluminium tetrahydride; n-butyllithium; diethylamino-sulfur trifluoride; ammonium acetate; benzotriazol-1-ol; toluene-4-sulfonic acid; N-cyclohexyl-cyclohexanamine; In tetrahydrofuran; ethanol; hexane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetone; toluene;

Reference yield:

: 1541198-16-6
C₁₇H₂₃ClFNO₃

: 1541199-21-6
(3S)-ethyl 3-(3-chloro-5-(4-(fluoromethyl)tetrahydro-2H-pyran-4-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 2,6-dimethylpyridine / dichloromethane / 10 h / 20 °C

2.1: Resolution of racemate

3.1: hydrogenchloride / ethyl acetate / 1 h

4.1: benzotriazol-1-ol / N,N-dimethyl-formamide; dichloromethane / 0.17 h / 20 °C / Inert atmosphere

4.2: 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; hydrogenchloride; benzotriazol-1-ol; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;