(phenylacetyl)-1-benzyl-2(S)-malyl-5(S)-amino-4(S)-<(tert-butyldimethylsilyl)oxy>-2(S)-isopropyl-7-(methyloctanoyl)-2(S)-methylbutylamine

Base Information

Chemical Name:(phenylacetyl)-1-benzyl-2(S)-malyl-5(S)-amino-4(S)-<(tert-butyldimethylsilyl)oxy>-2(S)-isopropyl-7-(methyloctanoyl)-2(S)-methylbutylamine
CAS No.:126082-59-5
Molecular Formula:C₄₂H₆₆N₂O₇Si
Molecular Weight:739.081
Hs Code.:

Synonyms:(phenylacetyl)-1-benzyl-2(S)-malyl-5(S)-amino-4(S)-<(tert-butyldimethylsilyl)oxy>-2(S)-isopropyl-7-(methyloctanoyl)-2(S)-methylbutylamine

Suppliers and Price of (phenylacetyl)-1-benzyl-2(S)-malyl-5(S)-amino-4(S)-<(tert-butyldimethylsilyl)oxy>-2(S)-isopropyl-7-(methyloctanoyl)-2(S)-methylbutylamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (phenylacetyl)-1-benzyl-2(S)-malyl-5(S)-amino-4(S)-<(tert-butyldimethylsilyl)oxy>-2(S)-isopropyl-7-(methyloctanoyl)-2(S)-methylbutylamine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (phenylacetyl)-1-benzyl-2(S)-malyl-5(S)-amino-4(S)-<(tert-butyldimethylsilyl)oxy>-2(S)-isopropyl-7-(methyloctanoyl)-2(S)-methylbutylamine

There total 5 articles about (phenylacetyl)-1-benzyl-2(S)-malyl-5(S)-amino-4(S)-<(tert-butyldimethylsilyl)oxy>-2(S)-isopropyl-7-(methyloctanoyl)-2(S)-methylbutylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 124322-26-5
1-benzyl-2(S)-malyl-5(S)-amino-4(S)-<(tert-butyldimethylsilyl)oxy>-2(S)-isopropyl-7-(methyloctanoyl)-2(S)-methylbutylamine

: 103-80-0
phenylacetyl chloride

: 126082-59-5
(phenylacetyl)-1-benzyl-2(S)-malyl-5(S)-amino-4(S)-<(tert-butyldimethylsilyl)oxy>-2(S)-isopropyl-7-(methyloctanoyl)-2(S)-methylbutylamine

Guidance literature:: With dmap; In dichloromethane; Ambient temperature;
DOI:10.1021/jm00167a009

Reference yield:

: 34985-37-0
(S)-2-methylbutylamine

: 126082-59-5
(phenylacetyl)-1-benzyl-2(S)-malyl-5(S)-amino-4(S)-<(tert-butyldimethylsilyl)oxy>-2(S)-isopropyl-7-(methyloctanoyl)-2(S)-methylbutylamine

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / diisopropylethylamine, diethylphosphoryl cyanide (DEPC) / 6 h / Ambient temperature

2: 173 mg / trifluoroacetic acid (TFA) / CH₂Cl₂ / 0.75 h / Ambient temperature

3: 49 percent / diisopropylethylamine, diethylphosphoryl cyanide (DEPC) / CH₂Cl₂ / Ambient temperature

4: 73 percent / 4-(dimethylamino)pyridine (DMAP) / CH₂Cl₂ / Ambient temperature

With dmap; diethylphosphoryl cyanide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jm00167a009

Reference yield:

: 123471-20-5
(2S,4S,5S)-5-Amino-4-(tert-butyl-dimethyl-silanyloxy)-2-isopropyl-7-methyl-octanoic acid ((S)-2-methyl-butyl)-amide

: 126082-59-5
(phenylacetyl)-1-benzyl-2(S)-malyl-5(S)-amino-4(S)-<(tert-butyldimethylsilyl)oxy>-2(S)-isopropyl-7-(methyloctanoyl)-2(S)-methylbutylamine

Guidance literature:: Multi-step reaction with 2 steps

1: 49 percent / diisopropylethylamine, diethylphosphoryl cyanide (DEPC) / CH₂Cl₂ / Ambient temperature

2: 73 percent / 4-(dimethylamino)pyridine (DMAP) / CH₂Cl₂ / Ambient temperature

With dmap; diethylphosphoryl cyanide; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1021/jm00167a009