CAS No.156-38-7,4-Hydroxyphenylacetic acid Suppliers

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Basic Information

Molecular Structure:
CAS No.:	156-38-7
Name:	4-Hydroxyphenylacetic acid
Article Data:	132

Formula:	C₈H₈O₃
Molecular Weight:	152.15
Synonyms:	Acetic acid, (p-hydroxyphenyl)-;4-HPA;2-(4-hydroxyphenyl)acetate;Para Hydroxy Phenyl Acetic;P-Hydroxyphenyl acetic acid;4-Hydroxy Phenyl Acetic Acid;4-Hydroxyphenylaceticacid;4-Hydroxyphenyl acetic acid;4-Carboxymethylphenol;benzeneacetic acid, 4-hydroxy-;4-10-00-00543 (Beilstein Handbook Reference);(p-Hydroxyphenyl)acetic acid;
EINECS:	205-851-3
Density:	1.319 g/cm³
Melting Point:	148-151 °C(lit.)
Boiling Point:	346.6 °C at 760 mmHg
Flash Point:	177.6 °C
Solubility:	Soluble in dimethyl sulfoxide and methanol. Slightly soluble in water.
Appearance:	white or light yellow crystalline powder
Hazard Symbols:	Xi
Risk Codes:	36/37/38
Safety:	26-36-24/25
PSA:	57.53000
LogP:	1.01930

Synthetic route

4-Methoxyphenylacetic acid: 4-Methoxyphenylacetic acid

: 156-38-7
4-hydroxyphenylacetate

Conditions

Conditions	Yield
With boron tribromide In dichloromethane at -78 - -15℃; for 4h; Inert atmosphere;	99%
With boron tribromide In dichloromethane at -78℃; for 0.5h;	93%
With hydrogen bromide; cetyltributylphosphonium bromide for 7.5h; Heating;	87%

: 58609-13-5
4-(benzyloxy)phenylacetic acid benzyl ester

: 156-38-7
4-hydroxyphenylacetate

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In methanol at 20℃; for 3h;	99%

: 2-(diethylamino)-1-(4-hydroxyphenyl)ethanone hydrochloride

A: 156-38-7
4-hydroxyphenylacetate

B: 660-68-4
diethyl amine hydrochloride

Conditions

Conditions	Yield
In aq. buffer pH=4 - 7.4; pH-value; Irradiation;	A 99% B 99%

: 1-(4-hydroxyphenyl)-2-(piperidin-1-yl)ethanone hydrobromide

A: 156-38-7
4-hydroxyphenylacetate

B: 14066-85-4
piperidine hydrobromide

Conditions

Conditions	Yield
In aq. acetate buffer pH=5.6; pH-value; Irradiation;	A 99% B 99%

: 19745-72-3
ω-amino-4-hydroxyacetophenone hydrochloride

: 156-38-7
4-hydroxyphenylacetate

Conditions

Conditions	Yield
In aq. acetate buffer pH=5.6; pH-value; Irradiation;	99%

: 7400-08-0
p-Coumaric Acid

A: 156-38-7
4-hydroxyphenylacetate

B: 501-94-0
p-hydroxyphenethyl alcohol

Conditions

Conditions	Yield
With β-D-glucose; oxygen for 18h; Reagent/catalyst; Enzymatic reaction;	A n/a B 97.3%

aqueous sulphuric acid: aqueous sulphuric acid

: 4-hydroxymandelic acid sodium salt monohydrate

aqueous chromic chloride: aqueous chromic chloride

: 156-38-7
4-hydroxyphenylacetate

Conditions

Conditions	Yield
With zinc In water; paraffin oil	97%

...Expand

: 52449-43-1
(4-chloro-phenyl)-acetic acid methyl ester

: 156-38-7
4-hydroxyphenylacetate

Conditions

Conditions	Yield
With sodium hydroxide	96%

: BrH*C9H11NO2

A: 156-38-7
4-hydroxyphenylacetate

B: 6876-37-5
methylammonium bromide

Conditions

Conditions	Yield
In water pH=5.6; pH-value; Irradiation;	A 95% B 95%

: 2-fluoro-1-(4-hydroxyphenyl)ethanone

: 156-38-7
4-hydroxyphenylacetate

Conditions

Conditions	Yield
In acetonitrile Quantum yield; Solvent; UV-irradiation;	95%

Raw Materials

104-47-2

64-17-5

Downstream Products

Total:180 Page 1 of 5 1 2 3 4 5 Next>>

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Consensus Reports

Reported in EPA TSCA Inventory.

Specification

4-Hydroxyphenylacetic acid, with the CAS NO.156-38-7, is an important intermediate which is used for syntheses of substances useful for pharmaceuticals. Therefore, it is generally beneficial that the acid is advantageously manufactured on an industrial scale. It is also called (p-hydroxyphenyl)-aceticaci; 4-carboxymethylphenol; 4-hydroxy-benzeneaceticaci; 4-hydroxybenzeneaceticacid; 4-hydroxyphenylethanoicacid; Acetic acid, (p-hydroxyphenyl)-; ethanoicacid,4-hydroxyphenyl-.

Physical properties about 4-Hydroxyphenylacetic acid are: (1)ACD/LogP: 0.692; (2)ACD/LogD (pH 5.5): -0.39; (3)ACD/LogD (pH 7.4): -2.19; (4)ACD/BCF (pH 5.5): 1.00; (5)ACD/BCF (pH 7.4): 1.00; (6)ACD/KOC (pH 5.5):4.70; (7)ACD/KOC (pH 7.4): 1.00; (8)#H bond acceptors: 3; (9)#H bond donors: 2; (10)#Freely Rotating Bonds: 3; (11)Index of Refraction: 1.596; (12)Molar Refractivity: 39.248 cm³; (13)Molar Volume: 115.306 cm³; (14)Polarizability: 15.559 10-24cm³; (15)Surface Tension: 59.8230018615723 dyne/cm; (16)Density: 1.32 g/cm³; (17)Flash Point: 177.631 °C; (18)Enthalpy of Vaporization: 62.351 kJ/mol; (19)Boiling Point: 346.627 °C at 760 mmHg

Preparation of 4-Hydroxyphenylacetic acid: A method in which anisole, which is a starting material, is subjected to chloromethylation and a cyanation to be thereby converted to 4-methoxyphenylacetonitrile (Organikum, Berlin, nine edit., p. 363); and the resultant4-methoxyphenylacetonitrile is saponified to produce an acid, which is subsequently treated with hydriodic acid to eliminate an ether, whereby 4-hydroxyphenylacetic acid is obtained as the desired product.

When you are using this chemical, please be cautious about it as the following:
1. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice;
2. Wear suitable protective clothing;
3. Avoid contact with skin and eyes;

You can still convert the following datas into molecular structure:
(1)InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11);
(2)InChIKey=XQXPVVBIMDBYFF-UHFFFAOYSA-N;
(3)Smilesc1(ccc(O)cc1)CC(O)=O;

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	3500mg/kg (3500mg/kg)		Farmaco, Edizione Scientifica. Vol. 13, Pg. 286, 1958.