N-{2-[4-(4-benzyloxy-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-3-hydroxy-benzamide

Base Information

Chemical Name:N-{2-[4-(4-benzyloxy-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-3-hydroxy-benzamide
CAS No.:1215855-24-5
Molecular Formula:C₂₆H₂₇N₃O₄
Molecular Weight:445.518
Hs Code.:

Synonyms:N-{2-[4-(4-benzyloxy-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-3-hydroxy-benzamide

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Chemical Property of N-{2-[4-(4-benzyloxy-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-3-hydroxy-benzamide

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Technology Process of N-{2-[4-(4-benzyloxy-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-3-hydroxy-benzamide

There total 8 articles about N-{2-[4-(4-benzyloxy-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-3-hydroxy-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1215855-23-4
acetic acid 3-{2-[4-(4-benzyloxy-phenyl)-piperazin-1-yl]-2-oxo-ethylcarbamoyl}-phenyl ester

: 1215855-24-5
N-{2-[4-(4-benzyloxy-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-3-hydroxy-benzamide

Guidance literature:: acetic acid 3-{2-[4-(4-benzyloxy-phenyl)-piperazin-1-yl]-2-oxo-ethylcarbamoyl}-phenyl ester; With water; sodium hydroxide; In ethanol; at 0 ℃; for 1h;

With acetic acid; In ethanol; pH=< 7;

Reference yield:

: 1215855-21-2
(3-acetoxy-benzoylamino)-acetic acid benzyl ester

: 1215855-24-5
N-{2-[4-(4-benzyloxy-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-3-hydroxy-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C

2.1: triethylamine / tetrahydrofuran / -15 °C

3.1: triethylamine / dichloromethane; tetrahydrofuran / 10 - 20 °C

4.1: sodium hydroxide / ethanol / 0 °C

4.2: pH < 7

With hydrogen; triethylamine; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane;

Reference yield:

: 6793-92-6
p-benzyloxyphenylbromide

: 1215855-24-5
N-{2-[4-(4-benzyloxy-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-3-hydroxy-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium t-butanolate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene; tetrahydrofuran / 20 °C / Reflux

2.1: triethylamine / dichloromethane; tetrahydrofuran / 10 - 20 °C

3.1: sodium hydroxide / ethanol / 0 °C

3.2: pH < 7

With 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; sodium hydroxide; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; toluene;