(E)-3-chloro-N-(4-((6-(3-chloropropanamido)-9-oxo-1,2-dihydropyrrolo[2,1-b]quinazolin-3(9H)-ylidene)methyl)phenyl)propanamide

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Chemical Name:(E)-3-chloro-N-(4-((6-(3-chloropropanamido)-9-oxo-1,2-dihydropyrrolo[2,1-b]quinazolin-3(9H)-ylidene)methyl)phenyl)propanamide
CAS No.:1148033-99-1
Molecular Formula:C₂₄H₂₂Cl₂N₄O₃
Molecular Weight:485.37
Hs Code.:

Synonyms:(E)-3-chloro-N-(4-((6-(3-chloropropanamido)-9-oxo-1,2-dihydropyrrolo[2,1-b]quinazolin-3(9H)-ylidene)methyl)phenyl)propanamide

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Chemical Property of (E)-3-chloro-N-(4-((6-(3-chloropropanamido)-9-oxo-1,2-dihydropyrrolo[2,1-b]quinazolin-3(9H)-ylidene)methyl)phenyl)propanamide

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Technology Process of (E)-3-chloro-N-(4-((6-(3-chloropropanamido)-9-oxo-1,2-dihydropyrrolo[2,1-b]quinazolin-3(9H)-ylidene)methyl)phenyl)propanamide

There total 4 articles about (E)-3-chloro-N-(4-((6-(3-chloropropanamido)-9-oxo-1,2-dihydropyrrolo[2,1-b]quinazolin-3(9H)-ylidene)methyl)phenyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1148033-95-7
(E)-6-amino-3-(4-aminobenzylidene)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one

: 625-36-5
2-chloropropionyl chloride

: 1148033-99-1
(E)-3-chloro-N-(4-((6-(3-chloropropanamido)-9-oxo-1,2-dihydropyrrolo[2,1-b]quinazolin-3(9H)-ylidene)methyl)phenyl)propanamide

Guidance literature:: for 4h; Reflux;
DOI:10.1021/jm801600m

Reference yield:

: 1148034-07-4
C₁₈H₁₂N₄O₅

: 1148033-99-1
(E)-3-chloro-N-(4-((6-(3-chloropropanamido)-9-oxo-1,2-dihydropyrrolo[2,1-b]quinazolin-3(9H)-ylidene)methyl)phenyl)propanamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodiumsulfide nonahydrate; sodium hydroxide / ethanol; water / Reflux

2: 4 h / Reflux

With sodiumsulfide nonahydrate; sodium hydroxide; In ethanol; water;
DOI:10.1039/c1ob05884c

Reference yield:

: 619-17-0
4-Nitroanthranilic acid

: 1148033-99-1
(E)-3-chloro-N-(4-((6-(3-chloropropanamido)-9-oxo-1,2-dihydropyrrolo[2,1-b]quinazolin-3(9H)-ylidene)methyl)phenyl)propanamide

Guidance literature:: Multi-step reaction with 4 steps

1: trichlorophosphate / toluene / Reflux

2: acetic anhydride / Reflux

3: sodiumsulfide nonahydrate; sodium hydroxide / ethanol; water / Reflux

4: 4 h / Reflux

With sodiumsulfide nonahydrate; acetic anhydride; sodium hydroxide; trichlorophosphate; In ethanol; water; toluene;
DOI:10.1039/c1ob05884c