Cyano-[2-methyl-3-oxo-5-phenyl-2,3-dihydro-isoindol-(1Z)-ylidene]-acetic acid ethyl ester

Base Information

Chemical Name:Cyano-[2-methyl-3-oxo-5-phenyl-2,3-dihydro-isoindol-(1Z)-ylidene]-acetic acid ethyl ester
CAS No.:127907-32-8
Molecular Formula:C₂₀H₁₆N₂O₃
Molecular Weight:332.359
Hs Code.:

Synonyms:Cyano-[2-methyl-3-oxo-5-phenyl-2,3-dihydro-isoindol-(1Z)-ylidene]-acetic acid ethyl ester

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Chemical Property of Cyano-[2-methyl-3-oxo-5-phenyl-2,3-dihydro-isoindol-(1Z)-ylidene]-acetic acid ethyl ester

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Technology Process of Cyano-[2-methyl-3-oxo-5-phenyl-2,3-dihydro-isoindol-(1Z)-ylidene]-acetic acid ethyl ester

There total 5 articles about Cyano-[2-methyl-3-oxo-5-phenyl-2,3-dihydro-isoindol-(1Z)-ylidene]-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 15296-24-9
Cyano-[3-oxo-5-phenyl-2,3-dihydro-isoindol-(1Z)-ylidene]-acetic acid ethyl ester

: 74-88-4
methyl iodide

: 127907-32-8
Cyano-[2-methyl-3-oxo-5-phenyl-2,3-dihydro-isoindol-(1Z)-ylidene]-acetic acid ethyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 1h;
DOI:10.1021/jm00102a016

Reference yield:

: 63243-76-5
2-amino-5-bromobenzoic acid,ethyl ester

: 127907-32-8
Cyano-[2-methyl-3-oxo-5-phenyl-2,3-dihydro-isoindol-(1Z)-ylidene]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) aq. HCl, sodium nitrite / 2.) 70 deg C, 1 h

2: 72 percent / tetrakis(triphenylphosphine)palladium, 2.0 M aq. Na₂CO₃ / benzene / 4 h / Heating

3: ammonia gas / methanol / 72 h / Ambient temperature

4: 0.17 h / 160 °C

5: potassium carbonate / dimethylformamide / 1 h / 100 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonia; sodium carbonate; potassium carbonate; sodium nitrite; In methanol; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm00102a016

Reference yield:

: 127510-93-4
5-bromo-2-cyanobenzoic acid ethyl ester

: 127907-32-8
Cyano-[2-methyl-3-oxo-5-phenyl-2,3-dihydro-isoindol-(1Z)-ylidene]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 72 percent / tetrakis(triphenylphosphine)palladium, 2.0 M aq. Na₂CO₃ / benzene / 4 h / Heating

2: ammonia gas / methanol / 72 h / Ambient temperature

3: 0.17 h / 160 °C

4: potassium carbonate / dimethylformamide / 1 h / 100 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonia; sodium carbonate; potassium carbonate; In methanol; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm00102a016