methyl 3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-[3-(trifluoromethyl)phenyl]propanoate

Base Information

Chemical Name:methyl 3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-[3-(trifluoromethyl)phenyl]propanoate
CAS No.:1361319-26-7
Molecular Formula:C₁₉H₁₄F₃NO₄
Molecular Weight:377.32
Hs Code.:

Synonyms:methyl 3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-[3-(trifluoromethyl)phenyl]propanoate

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Chemical Property of methyl 3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-[3-(trifluoromethyl)phenyl]propanoate

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Technology Process of methyl 3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-[3-(trifluoromethyl)phenyl]propanoate

There total 1 articles about methyl 3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-[3-(trifluoromethyl)phenyl]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 5332-26-3
N-(bromomethyl)phtalimide

: 62451-84-7
(3-trifluoromethyl-phenyl)-acetic acid methyl ester

: 1361319-26-7
methyl 3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-[3-(trifluoromethyl)phenyl]propanoate

Guidance literature:: (3-trifluoromethyl-phenyl)-acetic acid methyl ester; With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 0.333333h;

N-(bromomethyl)phtalimide; In tetrahydrofuran; hexane; at -78 - 20 ℃;

Reference yield:

: 1361319-26-7
methyl 3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-[3-(trifluoromethyl)phenyl]propanoate

: 1361319-62-1
3-amino-2-[3-(trifluoromethyl)phenyl]propan-1-ol

Guidance literature:: methyl 3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-[3-(trifluoromethyl)phenyl]propanoate; With sodium tetrahydroborate; water; In isopropyl alcohol;

With water; acetic acid; In isopropyl alcohol; at 80 ℃; pH=5;

Reference yield:

: 1361319-26-7
methyl 3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-[3-(trifluoromethyl)phenyl]propanoate

: 1361319-27-8
tert-butyl {3-hydroxy-2-[3-(trifluoromethyl)phenyl]propyl}carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; sodium tetrahydroborate / isopropyl alcohol

1.2: 80 °C / pH 5

2.1: sodium hydrogencarbonate / acetonitrile; water / 20 °C

With sodium tetrahydroborate; water; sodium hydrogencarbonate; In water; isopropyl alcohol; acetonitrile;