3-[(tert-butoxycarbonyl)amino]-2-[3-(trifluoromethyl)phenyl]propyl ethylcarbamate

Base Information

Chemical Name:3-[(tert-butoxycarbonyl)amino]-2-[3-(trifluoromethyl)phenyl]propyl ethylcarbamate
CAS No.:1361319-29-0
Molecular Formula:C₁₈H₂₅F₃N₂O₄
Molecular Weight:390.403
Hs Code.:

Synonyms:3-[(tert-butoxycarbonyl)amino]-2-[3-(trifluoromethyl)phenyl]propyl ethylcarbamate

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Chemical Property of 3-[(tert-butoxycarbonyl)amino]-2-[3-(trifluoromethyl)phenyl]propyl ethylcarbamate

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Technology Process of 3-[(tert-butoxycarbonyl)amino]-2-[3-(trifluoromethyl)phenyl]propyl ethylcarbamate

There total 4 articles about 3-[(tert-butoxycarbonyl)amino]-2-[3-(trifluoromethyl)phenyl]propyl ethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1361319-27-8
tert-butyl {3-hydroxy-2-[3-(trifluoromethyl)phenyl]propyl}carbamate

: 109-90-0
ethyl isocyanate

: 1361319-29-0
3-[(tert-butoxycarbonyl)amino]-2-[3-(trifluoromethyl)phenyl]propyl ethylcarbamate

Guidance literature:: With pyridine; dmap; at 20 - 50 ℃;

Reference yield:

: 1361319-26-7
methyl 3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-[3-(trifluoromethyl)phenyl]propanoate

: 1361319-29-0
3-[(tert-butoxycarbonyl)amino]-2-[3-(trifluoromethyl)phenyl]propyl ethylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: water; sodium tetrahydroborate / isopropyl alcohol

1.2: 80 °C / pH 5

2.1: sodium hydrogencarbonate / acetonitrile; water / 20 °C

3.1: dmap; pyridine / 20 - 50 °C

With pyridine; dmap; sodium tetrahydroborate; water; sodium hydrogencarbonate; In water; isopropyl alcohol; acetonitrile;

Reference yield:

: 62451-84-7
(3-trifluoromethyl-phenyl)-acetic acid methyl ester

: 1361319-29-0
3-[(tert-butoxycarbonyl)amino]-2-[3-(trifluoromethyl)phenyl]propyl ethylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium; diisopropylamine; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / tetrahydrofuran; hexane / 0.33 h / -78 °C

1.2: -78 - 20 °C

2.1: water; sodium tetrahydroborate / isopropyl alcohol

2.2: 80 °C / pH 5

3.1: sodium hydrogencarbonate / acetonitrile; water / 20 °C

4.1: dmap; pyridine / 20 - 50 °C

With pyridine; dmap; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; sodium tetrahydroborate; n-butyllithium; water; sodium hydrogencarbonate; diisopropylamine; In tetrahydrofuran; hexane; water; isopropyl alcohol; acetonitrile;