Meldonium

Base Information Edit

Chemical Name:Meldonium
CAS No.:76144-81-5
Molecular Formula:C6H14N2O2
Molecular Weight:146.189
Hs Code.:
European Community (EC) Number:682-135-0
UNII:73H7UDN6EC
DSSTox Substance ID:DTXSID10997497
Wikipedia:Meldonium
Wikidata:Q4289752
NCI Thesaurus Code:C66079
Metabolomics Workbench ID:154508
ChEMBL ID:CHEMBL2104708
Mol file:76144-81-5.mol

Synonyms:3-(2,2,2-trimethylhydrazine)propionate;3-(2,2,2-trimethylhydrazinium)propionate;3-TMHP;meldonium;MET-88;mildronat;mildronate;mindronate;N-trimethylhydrazine-3-propionate;Q-4224-IOS;Quaterin;trimethylhydraziniumpropionate;Vasonat

This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Meldonium Edit

Chemical Property:

Appearance/Colour:White crystalline powder
Melting Point:85-90 °C
Refractive Index:1.598
Storage Temp.:Refrigerator
Solubility.:Methanol (Slightly), Water (Slightly)
XLogP3:-2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:146.105527694
Heavy Atom Count:10
Complexity:112

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C[N+](C)(C)NCCC(=O)[O-]
Recent ClinicalTrials:Safety and Efficacy of the Therapy With BREINMAX? for the Treatment of Patients With Asthenia After COVID-19
Recent EU Clinical Trials:Mildronate - Efficacy And Safety Of Treatment For Chronic Coronary Heart Disease (Stable Angina) I
Description Mildronate is a cardiac and neuroprotective drug. It is a compound with a new structure first developed by Latvia Institute of Organic Synthesis. It was first developed by Grindeks in the former Soviet Union in 1989. On the market, the drug is a structural analog of carnitine, which can compete with carnitine for γ-trimethylaminobutyrate hydroxylase, reduce the concentration of free carnitine and long-chain acetylcarnitine in cells, so it can inhibit Carnitine-dependent fatty acid oxidation. Meldonium was added to the WADA list of banned substances on January 1, 2016 because of "evidence of its use by athletes with the intention of enhancing performance."
Uses Mildronate is a drug used to treat angina, myocardial infarction, and chronic heart failure. It is a novel pharmaceutical composition based on a reverse transcriptase inhibitor and meldonium.This compound generally contains a significant amount of water.

Technology Process of Meldonium

There total 11 articles about Meldonium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 76144-82-6
methyl 3-(2,2,2-trimethylhydrazinium)propionate chloride

: 76144-81-5
meldonium

Guidance literature:: methyl 3-(2,2,2-trimethylhydrazinium)propionate chloride; With ethanol; sodium hydroxide; at 18 - 20 ℃;

With carbon dioxide; pH=8.1 - 8.5; Product distribution / selectivity;