(3S,4S)-3-<(S)-1-Hydroxyethyl>-1-<(4-methoxyphenyl)methyl>-4-<(phenylthio)methyl>-2-azetidinone

Base Information

Chemical Name:(3S,4S)-3-<(S)-1-Hydroxyethyl>-1-<(4-methoxyphenyl)methyl>-4-<(phenylthio)methyl>-2-azetidinone
CAS No.:161806-10-6
Molecular Formula:C₂₀H₂₃NO₃S
Molecular Weight:357.474
Hs Code.:

Synonyms:(3S,4S)-3-<(S)-1-Hydroxyethyl>-1-<(4-methoxyphenyl)methyl>-4-<(phenylthio)methyl>-2-azetidinone

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Chemical Property of (3S,4S)-3-<(S)-1-Hydroxyethyl>-1-<(4-methoxyphenyl)methyl>-4-<(phenylthio)methyl>-2-azetidinone

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Technology Process of (3S,4S)-3-<(S)-1-Hydroxyethyl>-1-<(4-methoxyphenyl)methyl>-4-<(phenylthio)methyl>-2-azetidinone

There total 2 articles about (3S,4S)-3-<(S)-1-Hydroxyethyl>-1-<(4-methoxyphenyl)methyl>-4-<(phenylthio)methyl>-2-azetidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 153924-18-6
(3S,4S)-3-<(S)-1-Hydroxyethyl>-1-<(4-methoxyphenyl)methyl>-4--2-azetidinone

: 161806-10-6
(3S,4S)-3-<(S)-1-Hydroxyethyl>-1-<(4-methoxyphenyl)methyl>-4-<(phenylthio)methyl>-2-azetidinone

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; for 14h; Heating;
DOI:10.1021/jo00110a035

Reference yield:

: (3SR,4SR)-3-<(S)-1-Acetoxyethyl>-1-<(4-methoxyphenyl)methyl>-4--2-azetidinone

: 161806-10-6
(3S,4S)-3-<(S)-1-Hydroxyethyl>-1-<(4-methoxyphenyl)methyl>-4-<(phenylthio)methyl>-2-azetidinone

Guidance literature:: Multi-step reaction with 2 steps

1: 56 percent / 0.1 N aq. NaOH / pyridine / Ambient temperature

2: 97 percent / Bu₃SnH, AIBN / toluene / 14 h / Heating

With sodium hydroxide; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In pyridine; toluene;
DOI:10.1021/jo00110a035

Reference yield: 79.0%

: 64-18-6
formic acid

: 161806-10-6
(3S,4S)-3-<(S)-1-Hydroxyethyl>-1-<(4-methoxyphenyl)methyl>-4-<(phenylthio)methyl>-2-azetidinone

: 161806-11-7
(3S,4S)-3-<(R)-1-(Formyloxy)ethyl>-1-<(4-methoxyphenyl)methyl>-4-<(phenylthio)methyl>-2-azetidinone

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; for 2h; Ambient temperature;
DOI:10.1021/jo00110a035