C₄₈H₅₃N₇O₁₀S

Base Information

Chemical Name:C₄₈H₅₃N₇O₁₀S
CAS No.:1346434-70-5
Molecular Formula:C₄₈H₅₃N₇O₁₀S
Molecular Weight:920.056
Hs Code.:

C<sub>48</sub>H<sub>53</sub>N<sub>7</sub>O<sub>10</sub>S

Synonyms:C₄₈H₅₃N₇O₁₀S

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Chemical Property of C₄₈H₅₃N₇O₁₀S

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Technology Process of C₄₈H₅₃N₇O₁₀S

There total 10 articles about C₄₈H₅₃N₇O₁₀S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1346434-61-4
O-[1-(phenylsulfonyl)-7-azido-2-heptyl]-N-[4-(diethylcarboxamido)phenyl]-N-chloromethyl carbamate

: 86639-52-3,110714-48-2,130144-34-2,113015-38-6,647852-82-2
7-ethyl-10-hydroxycamptothecin

: 1346434-70-5
C₄₈H₅₃N₇O₁₀S

Guidance literature:: 7-ethyl-10-hydroxycamptothecin; With pyridine; potassium tert-butylate; In tetrahydrofuran; N,N-dimethyl-formamide; for 0.25h; Cooling with ice; Inert atmosphere;

O-[1-(phenylsulfonyl)-7-azido-2-heptyl]-N-[4-(diethylcarboxamido)phenyl]-N-chloromethyl carbamate; In tetrahydrofuran; N,N-dimethyl-formamide; at 4 - 20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jm401644v

Reference yield:

: 122-04-3
4-nitro-benzoyl chloride

: 1346434-70-5
C₄₈H₅₃N₇O₁₀S

Guidance literature:: Multi-step reaction with 5 steps

1.1: dichloromethane / 1 h / Cooling with ice

2.1: ammonium formate / palladium 10% on activated carbon / methanol / 2 h / 20 °C

3.1: triethylamine / tetrahydrofuran / 1 h

4.1: chloro-trimethyl-silane; triethylamine / tetrahydrofuran / 17 h / 55 °C

5.1: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / -78 °C

5.2: 0.17 h / 20 °C

With chloro-trimethyl-silane; ammonium formate; triethylamine; lithium hexamethyldisilazane; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 5323-47-7
N,N-diethyl-4-nitrobenzamide

: 1346434-70-5
C₄₈H₅₃N₇O₁₀S

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonium formate / palladium 10% on activated carbon / methanol / 2 h / 20 °C

2.1: triethylamine / tetrahydrofuran / 1 h

3.1: chloro-trimethyl-silane; triethylamine / tetrahydrofuran / 17 h / 55 °C

4.1: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / -78 °C

4.2: 0.17 h / 20 °C

With chloro-trimethyl-silane; ammonium formate; triethylamine; lithium hexamethyldisilazane; palladium 10% on activated carbon; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;