Chemical Property of Tetradecylthioacetic acid
Chemical Property:
- Appearance/Colour:white cyrstalline solid
- Vapor Pressure:1.32E-07mmHg at 25°C
- Melting Point:65-73 °C
- Refractive Index:1.481
- Boiling Point:402.6 °C at 760 mmHg
- PKA:3.85±0.10(Predicted)
- Flash Point:197.3 °C
- PSA：62.60000
- Density:0.957 g/cm3
- LogP:5.50530
- Storage Temp.:-20°C Freezer
- Solubility.:DMSO: ≥22 mg/mL, soluble
- XLogP3:7.1
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:3
- Rotatable Bond Count:15
- Exact Mass:288.21230143
- Heavy Atom Count:19
- Complexity:195
- Purity/Quality:
-
99% *data from raw suppliers
Tetradecylthioacetic Acid *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CCCCCCCCCCCCCCSCC(=O)O
- Recent ClinicalTrials:TTA in Treatment of Diabetes and Dyslipidemia
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Description
Tetradecylthioacetic acid (TTA), a representative member of the 3-thia family, has the chemical structure of palmitic acid (C16) in which a sulfur atom is located between the 2 and 3-carbon atoms (COOH-CH2-S-(CH2)13-CH3). TTA is a novel hypolipidemic drug which has been shown to combine several effects of w-3 PUFAs, such as EPA, and structurally unrelated peroxisome proliferators, such as phenylacetate and fibrates. From this perspective we wanted to investigate if TTA shares the antitumor activity found for these functionally related compounds, and furthermore to study the metabolic effects of TTA in cancer cells in relation to the effects found in hepatocytes.
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Uses
TTA is a novel thio-fatty acid which cannot undergo beta-oxidation. It induces apoptosis in IPC-81 leukemia cells via depolarization of mitochondrial membrane potential and inhibits glioma cell proliferation. TTA completely prevents high fat diet-induce TTA is a novel thio-fatty acid which cannot undergo beta-oxidation. It induces apoptosis in IPC-81 leukemia cells via depolarization of mitochondrial membrane potential and inhibits glioma cell proliferation. TTA completely prevents high fat diet-induced insulin resistance and adiposity in Wistar rats. Activates rodent PPAR’s with rank order PPARα>PPARδ>PPARγ.
