2079-95-0

Basic information

• Product Name: 1-Tetradecanethiol
• Synonyms: 1-TETRADECANETHIOL;1-Mercaptotetradecane;n-tetradecanethiol;Tetradecanethiol-(1);tetradecanethiol(non-specificname);tetradecanethiolnormal;TETRADECYLMERCAPTAN;TETRADECANE THIOL
• CAS NO: 2079-95-0
• Molecular Formula: C₁₄H₃₀S
• Molecular Weight: 230.45
• EINECS: 218-209-2
• Product Categories: Phenoles and thiophenoles
• Mol File: 2079-95-0.mol
• Article Data: 2

Chemical Properties

• Melting Point: 6-7°C
• Boiling Point: 176-180°C 22mm
• Flash Point: 176-180°C/22mm
• Appearance: /
• Density: 0.846 g/mL at 20 °C(lit.)
• Vapor Pressure: 0.00135mmHg at 25°C
• Refractive Index: n20/D 1.461
• PKA: 10.49±0.10(Predicted)
• Sensitive: Air Sensitive
• BRN: 1742653
• CAS DataBase Reference: 1-Tetradecanethiol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Tetradecanethiol(2079-95-0)
• EPA Substance Registry System: 1-Tetradecanethiol(2079-95-0)

Safety Data

• Hazard Codes: Xi
• Statements: 41-43
• Safety Statements: 26-36/37/39
• RIDADR: UN 3334
• WGK Germany: 3
• F: 9-13-23
• TSCA: Yes
• Hazardous Substances Data: 2079-95-0(Hazardous Substances Data)

Usage

Chemical Properties

Colorless liquid

Uses

TDT is used as a self-assembled monolayer (SAM) on gold nanoparticle(AuNP) based electrodes for bi-enzymer glucose biosensors. The surface modification was done by soaking the electrodes in TDT solution.

General Description

1-Tetradecanethiol (TDT) is an alkanethiol used as a self-assembled monolayer (SAM) which may be used to functionalize a variety of nanoparticles. It is a hydrophobic ligand. It is highly oriented and acts as a hole-injection barrier on the nanoparticle surface.

InChI:InChI=1/C14H30S/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15/h15H,2-14H2,1H3

Upstream product

• 112-71-0 1-Bromotetradecane 
• 90031-26-8 S-tetradecyl thioacetate 
• 41446-63-3 (E)-7-tetradecene 
• 112-72-1 1-Tetradecanol 
• 5348-83-4 bis(tetradecyl)disulfide 

Downstream Products

• 2307-14-4 n-Tetradecylthiolaurat 
• 7148-21-2 trithioantimonous acid tritetradecyl ester 
• 2307-25-7 n-Tetradecylthiomyristat 
• 2307-40-6 thiostearic acid S-tetradecyl ester 
• 2307-32-6 n-Tetradecylthiopalmitat 
• 62443-28-1 4-Tetradecylsulfanyl-benzoic acid 
• 5348-83-4 bis(tetradecyl)disulfide 
• 65972-31-8 4-Nitrophenyl-tetradecyl-sulfid 
• 212513-22-9 methyl (R)-2-[((tetradecylthio)carbonyl)acetyloxy]-3-triphenylmethyloxypropionate 
• 2921-20-2 tetradecylthioacetic Acid 

Relevant articles and documents

Synthesis of a tetronic acid library focused on inhibitors of tyrosine and dual-specificity protein phosphatases and its evaluation regarding VHR and Cdc25B inhibition

Selective inhibitors of protein tyrosine phosphatases (PTPs) and dual-specificity phosphatases (DSPs) are expected to be useful tools for clarifying the biological functions of the PTPs themselves and also to be candidates for novel therapeutics. We planned a library approach for the identification of PTP/DSP inhibitors in which 3-acyltetronic acid is used as a "core" phosphate mimic. A series of novel tetronic acid derivatives were synthesized and evaluated as inhibitors of the dual-specificity protein phosphatases VHR and cdc25B. Several compounds are found to be potent inhibitors of cdc25B, which is a key enzyme for cell-cycle progression. The promising results described herein strongly indicated that this tetronic acid library is potent as a library focused on the PTP/DSP-selective inhibitor.