(+/-)-methyl 6-[(cyclohexyl{2-[4-(trifluoromethyl)phenyl]pyrimidin-5-yl}methyl)amino]nicotinate

Base Information

Chemical Name:(+/-)-methyl 6-[(cyclohexyl{2-[4-(trifluoromethyl)phenyl]pyrimidin-5-yl}methyl)amino]nicotinate
CAS No.:1383801-42-0
Molecular Formula:C₂₅H₂₅F₃N₄O₂
Molecular Weight:470.494
Hs Code.:

Synonyms:(+/-)-methyl 6-[(cyclohexyl{2-[4-(trifluoromethyl)phenyl]pyrimidin-5-yl}methyl)amino]nicotinate

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Chemical Property of (+/-)-methyl 6-[(cyclohexyl{2-[4-(trifluoromethyl)phenyl]pyrimidin-5-yl}methyl)amino]nicotinate

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Technology Process of (+/-)-methyl 6-[(cyclohexyl{2-[4-(trifluoromethyl)phenyl]pyrimidin-5-yl}methyl)amino]nicotinate

There total 5 articles about (+/-)-methyl 6-[(cyclohexyl{2-[4-(trifluoromethyl)phenyl]pyrimidin-5-yl}methyl)amino]nicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383801-39-5
(+/-)-1-cyclohexyl-1-{2-[4-(trifluoromethyl)phenyl]pyrimidin-5-yl}methanamine

: 1427-06-1
methyl 6-fluoropyridine-3-carboxylate

: 1383801-42-0
(+/-)-methyl 6-[(cyclohexyl{2-[4-(trifluoromethyl)phenyl]pyrimidin-5-yl}methyl)amino]nicotinate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 120 ℃; for 12h;

Reference yield:

: 1383801-33-9
(+/-)-cyclohexyl{2-[4-(trifluoromethyl)phenyl]pyrimidin-5-yl}methanol

: 1383801-42-0
(+/-)-methyl 6-[(cyclohexyl{2-[4-(trifluoromethyl)phenyl]pyrimidin-5-yl}methyl)amino]nicotinate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; sulfur trioxide pyridine complex / dichloromethane; dimethyl sulfoxide / 13 h / 0 - 20 °C

2.1: sodium cyanoborohydride; ammonium acetate; methanol / 12 h / Reflux

2.2: 0.5 h

3.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 120 °C

With methanol; ammonium acetate; sulfur trioxide pyridine complex; sodium cyanoborohydride; potassium carbonate; triethylamine; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 403-45-2
6-fluoronicotinic acid

: 1383801-42-0
(+/-)-methyl 6-[(cyclohexyl{2-[4-(trifluoromethyl)phenyl]pyrimidin-5-yl}methyl)amino]nicotinate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 12 h / 120 °C

With potassium carbonate; In N,N-dimethyl-formamide;