(+/-)-1-cyclohexyl-1-{2-[4-(trifluoromethyl)phenyl]pyrimidin-5-yl}methanamine

Base Information

Chemical Name:(+/-)-1-cyclohexyl-1-{2-[4-(trifluoromethyl)phenyl]pyrimidin-5-yl}methanamine
CAS No.:1383801-39-5
Molecular Formula:C₁₈H₂₀F₃N₃
Molecular Weight:335.372
Hs Code.:

Synonyms:(+/-)-1-cyclohexyl-1-{2-[4-(trifluoromethyl)phenyl]pyrimidin-5-yl}methanamine

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Chemical Property of (+/-)-1-cyclohexyl-1-{2-[4-(trifluoromethyl)phenyl]pyrimidin-5-yl}methanamine

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Technology Process of (+/-)-1-cyclohexyl-1-{2-[4-(trifluoromethyl)phenyl]pyrimidin-5-yl}methanamine

There total 4 articles about (+/-)-1-cyclohexyl-1-{2-[4-(trifluoromethyl)phenyl]pyrimidin-5-yl}methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383801-36-2
cyclohexyl{2-[4-(trifluoromethyl)phenyl]pyrimidin-5-yl}methanone

: 1383801-39-5
(+/-)-1-cyclohexyl-1-{2-[4-(trifluoromethyl)phenyl]pyrimidin-5-yl}methanamine

Guidance literature:: cyclohexyl{2-[4-(trifluoromethyl)phenyl]pyrimidin-5-yl}methanone; With methanol; ammonium acetate; sodium cyanoborohydride; for 12h; Reflux;

With sodium hydroxide; In dichloromethane; water; for 0.5h;

Reference yield:

: 1383801-33-9
(+/-)-cyclohexyl{2-[4-(trifluoromethyl)phenyl]pyrimidin-5-yl}methanol

: 1383801-39-5
(+/-)-1-cyclohexyl-1-{2-[4-(trifluoromethyl)phenyl]pyrimidin-5-yl}methanamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; sulfur trioxide pyridine complex / dichloromethane; dimethyl sulfoxide / 13 h / 0 - 20 °C

2.1: sodium cyanoborohydride; ammonium acetate; methanol / 12 h / Reflux

2.2: 0.5 h

With methanol; ammonium acetate; sulfur trioxide pyridine complex; sodium cyanoborohydride; triethylamine; In dichloromethane; dimethyl sulfoxide;

Reference yield:

: 38980-96-0
4-(trifluoromethyl)benzimidamide hydrochloride

: 1383801-39-5
(+/-)-1-cyclohexyl-1-{2-[4-(trifluoromethyl)phenyl]pyrimidin-5-yl}methanamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium methylate / ethanol / 1 h / 90 °C

2.1: diethyl ether; tetrahydrofuran / 1 h / -78 °C

2.2: -78 - 20 °C

3.1: triethylamine; sulfur trioxide pyridine complex / dichloromethane; dimethyl sulfoxide / 13 h / 0 - 20 °C

4.1: sodium cyanoborohydride; ammonium acetate; methanol / 12 h / Reflux

4.2: 0.5 h

With methanol; ammonium acetate; sodium methylate; sulfur trioxide pyridine complex; sodium cyanoborohydride; triethylamine; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; dimethyl sulfoxide;