2-Ethoxybenzoyl chloride

Base Information

• Chemical Name: 2-Ethoxybenzoyl chloride
• CAS No.: 42926-52-3
• Molecular Formula: C9H9ClO2
• Molecular Weight: 184.622
• Hs Code.: 2918990090
• European Community (EC) Number: 256-003-4
• DSSTox Substance ID: DTXSID20195568
• Nikkaji Number: J310.005G
• Wikidata: Q72471321
• Mol file: 42926-52-3.mol

Synonyms:2-Ethoxybenzoyl chloride;42926-52-3;o-Ethoxybenzoyl chloride;2-ethoxybenzoylchloride;Benzoyl chloride, 2-ethoxy-;EINECS 256-003-4;o-ethoxy benzoyl chloride;2-Ethoxy-benzoyl Chloride;SCHEMBL990;2-ethoxy--benzoyl chloride;2-ethoxybenzoic acid chloride;2-Ethoxybenzoyl chloride, 97%;DTXSID20195568;MDKAAWDKKBFSTK-UHFFFAOYSA-N;BCP32125;MFCD00016348;AKOS009158892;AS-49358;E0676;FT-0612208;H11258;A826073;W-106252;F2190-0048;o-Ethoxybenzoyl chloride pound>>Benzoyl chloride, 2-ethoxy-

Chemical Property of 2-Ethoxybenzoyl chloride

Chemical Property:

• Appearance/Colour: COLORLESS TO YELLOW TO BROWN LIQUID
• Vapor Pressure: 0.00677mmHg at 25°C
• Refractive Index: 1.553
• Boiling Point: 270.6 °C at 760 mmHg
• Flash Point: 100.8 °C
• PSA: 26.30000
• Density: 1.18 g/cm³
• LogP: 2.46430
• Storage Temp.: Inert atmosphere,Room Temperature
• Sensitive.: Moisture Sensitive
• Solubility.: soluble in Benzene
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 184.0291072
• Heavy Atom Count: 12
• Complexity: 159

Purity/Quality:

98.0%Min ^*data from raw suppliers

2-Ethoxybenzoyl Chloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34-22
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=CC=CC=C1C(=O)Cl

Technology Process of 2-Ethoxybenzoyl chloride

There total 3 articles about 2-Ethoxybenzoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.7%

2-ethoxybenzoic acid (134-11-2) → 2-ethoxybenzoyl chloride (42926-52-3)

Guidance literature:

With phosgene; N,N-dimethyl-formamide; In acetone; at 50 ℃;

Reference yield:

methyl salicylate (119-36-8,8024-54-2) → 2-ethoxybenzoyl chloride (42926-52-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium hydroxide / acetone / 0.5 h / 20 °C

1.2: Reflux

2.1: methanol; sodium hydroxide / 50 °C

3.1: N,N-dimethyl-formamide; phosgene / acetone / 50 °C

With methanol; phosgene; N,N-dimethyl-formamide; potassium hydroxide; sodium hydroxide; In acetone;

Reference yield:

→ 2-ethoxybenzoyl chloride (42926-52-3)

Guidance literature:

upstream raw materials:

2-ethoxybenzoic acid

methyl salicylate

Downstream raw materials:

N,N-diethyl-2-ethoxybenzamide

2-ethoxy-benzoic acid-(2-dimethylamino-ethylamide); hydrochloride

2-ethoxy-benzoic acid-(N'-phenyl-hydrazide)

O''-(2-ethoxy-benzoyl)-erythromycin

Refernces

• 1、 Jevti?, Ivana I.,Do?en-Mi?ovi?, Ljiljana,Ivanovi?, Evica R.,Ivanovi?, Milovan D.. "Hofmann Rearrangement of Carboxamides Mediated by N-Bromoacetamide". . p. 1550 - 1560. Retrieved 2016/06/01.
• 2、 -. "METHOD FOR PRODUCING OXAZOLE COMPOUND". Page/Page column 73-74. . Retrieved 2014/03/25.