(S)-N-acetyl-3-phenyl-1,1,1-trifluoro-2-propyl amine

Base Information

• Chemical Name: (S)-N-acetyl-3-phenyl-1,1,1-trifluoro-2-propyl amine
• CAS No.: 1108200-12-9
• Molecular Formula: C₁₁H₁₂F₃NO
• Molecular Weight: 231.218
• Mol file: 1108200-12-9.mol

Synonyms:(S)-N-acetyl-3-phenyl-1,1,1-trifluoro-2-propyl amine

Chemical Property of (S)-N-acetyl-3-phenyl-1,1,1-trifluoro-2-propyl amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-N-acetyl-3-phenyl-1,1,1-trifluoro-2-propyl amine

There total 12 articles about (S)-N-acetyl-3-phenyl-1,1,1-trifluoro-2-propyl amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(Z)-N-(3,3,3-trifluoro-1-phenylprop-1-en-2-yl)acetamide → (S)-N-acetyl-3-phenyl-1,1,1-trifluoro-2-propyl amine (1108200-12-9)

Guidance literature:

With [Rh(COD)(ScRp-DuanPhos)]BF₄; hydrogen; In methanol; at 25 ℃; for 6h; under 3800.26 Torr; Reagent/catalyst; Pressure; Solvent; enantioselective reaction; Autoclave;

DOI:10.1021/acs.orglett.5b00087

Reference yield: 78.0%

Isopropyl acetate (108-21-4) + oxime de la trifluoro-methyl benzyl cetone (348-73-2) → (S)-N-acetyl-3-phenyl-1,1,1-trifluoro-2-propyl amine (1108200-12-9)

Guidance literature:

With Candida antarctica lipase B; Pd/Al₂O₃; hydrogen; triethylamine; In toluene; at 100 ℃; for 180h; under 1125.11 Torr; Temperature; enantioselective reaction; Molecular sieve; Autoclave; Enzymatic reaction;

DOI:10.1002/cctc.201402114

Reference yield:

(Z)-N-(3,3,3-trifluoro-1-phenylprop-1-en-2-yl)acetamide → (R)-N-acetyl-3-phenyl-1,1,1-trifluoro-2-propyl amine (1108200-17-4) + (S)-N-acetyl-3-phenyl-1,1,1-trifluoro-2-propyl amine (1108200-12-9)

Guidance literature:

With [(R)-(S)-JOSIPHOS Rh(COD)]BF₄; hydrogen; In methanol; at 25 ℃; for 6h; under 3800.26 Torr; Reagent/catalyst; enantioselective reaction; Autoclave;

DOI:10.1021/acs.orglett.5b00087

upstream raw materials:

3-trifluoromethyltetrahydroisoquinoline

Isopropyl acetate

oxime de la trifluoro-methyl benzyl cetone

1,1,1-Trifluoro-3-phenylpropan-2-one

Downstream raw materials:

3-trifluoromethyltetrahydroisoquinoline

C₁₂H₁₄F₃NO₂