2-(4-((3,5-dimethylisoxazol-4-yl)methoxy)phenyl)-N-(phenyl(4-(trifluoromethyl)phenyl)methyl)acetamide

Base Information

Chemical Name:2-(4-((3,5-dimethylisoxazol-4-yl)methoxy)phenyl)-N-(phenyl(4-(trifluoromethyl)phenyl)methyl)acetamide
CAS No.:1421837-81-1
Molecular Formula:C₂₈H₂₅F₃N₂O₃
Molecular Weight:494.513
Hs Code.:

Synonyms:2-(4-((3,5-dimethylisoxazol-4-yl)methoxy)phenyl)-N-(phenyl(4-(trifluoromethyl)phenyl)methyl)acetamide

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Chemical Property of 2-(4-((3,5-dimethylisoxazol-4-yl)methoxy)phenyl)-N-(phenyl(4-(trifluoromethyl)phenyl)methyl)acetamide

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Technology Process of 2-(4-((3,5-dimethylisoxazol-4-yl)methoxy)phenyl)-N-(phenyl(4-(trifluoromethyl)phenyl)methyl)acetamide

There total 5 articles about 2-(4-((3,5-dimethylisoxazol-4-yl)methoxy)phenyl)-N-(phenyl(4-(trifluoromethyl)phenyl)methyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 19788-37-5
4-chloromethyl-3,5-dimethylisoxazole

: 1443325-56-1
2-(4-hydroxyphenyl)-N-(phenyl(4-(trifluoromethyl)phenyl)methyl)acetamide

: 1421837-81-1
2-(4-((3,5-dimethylisoxazol-4-yl)methoxy)phenyl)-N-(phenyl(4-(trifluoromethyl)phenyl)methyl)acetamide

Guidance literature:: With tetra-(n-butyl)ammonium iodide; potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 100-58-3
phenylmagnesium bromide

: 1421837-81-1
2-(4-((3,5-dimethylisoxazol-4-yl)methoxy)phenyl)-N-(phenyl(4-(trifluoromethyl)phenyl)methyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 20 °C / Inert atmosphere; Reflux

1.2: 0.5 h / 20 °C / Inert atmosphere

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 2.5 h / 20 °C

3.1: tetra-(n-butyl)ammonium iodide; potassium carbonate / N,N-dimethyl-formamide / 20 °C

With tetra-(n-butyl)ammonium iodide; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 455-18-5
4-CF₃C₆H₄CN

: 1421837-81-1
2-(4-((3,5-dimethylisoxazol-4-yl)methoxy)phenyl)-N-(phenyl(4-(trifluoromethyl)phenyl)methyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 20 °C / Inert atmosphere; Reflux

1.2: 0.5 h / 20 °C / Inert atmosphere

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 2.5 h / 20 °C

3.1: tetra-(n-butyl)ammonium iodide; potassium carbonate / N,N-dimethyl-formamide / 20 °C

With tetra-(n-butyl)ammonium iodide; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;