(S)-2-((S)-2-(benzyloxy)-3-(4-(benzyloxy)phenyl)propanamido)-3-phenylpropanoic acid

Base Information

Chemical Name:(S)-2-((S)-2-(benzyloxy)-3-(4-(benzyloxy)phenyl)propanamido)-3-phenylpropanoic acid
CAS No.:1242104-15-9
Molecular Formula:C₃₂H₃₁NO₅
Molecular Weight:509.602
Hs Code.:

Synonyms:(S)-2-((S)-2-(benzyloxy)-3-(4-(benzyloxy)phenyl)propanamido)-3-phenylpropanoic acid

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Chemical Property of (S)-2-((S)-2-(benzyloxy)-3-(4-(benzyloxy)phenyl)propanamido)-3-phenylpropanoic acid

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Technology Process of (S)-2-((S)-2-(benzyloxy)-3-(4-(benzyloxy)phenyl)propanamido)-3-phenylpropanoic acid

There total 6 articles about (S)-2-((S)-2-(benzyloxy)-3-(4-(benzyloxy)phenyl)propanamido)-3-phenylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1242104-29-5
C₃₃H₃₃NO₅

: 1242104-15-9
(S)-2-((S)-2-(benzyloxy)-3-(4-(benzyloxy)phenyl)propanamido)-3-phenylpropanoic acid

Guidance literature:: With methanol; lithium hydroxide monohydrate; In tetrahydrofuran; water; at 20 ℃; for 0.5h;
DOI:10.1002/chem.201400046

Reference yield:

: 162919-37-1
(S)-3-[4-(benzyloxy)phenyl]-2-hydroxypropanoic acid

: 1242104-15-9
(S)-2-((S)-2-(benzyloxy)-3-(4-(benzyloxy)phenyl)propanamido)-3-phenylpropanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: dichloromethane; methanol; diethyl ether / 0.25 h / 0 - 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere

2.2: 1.5 h / 20 °C / Inert atmosphere

3.1: methanol; lithium hydroxide monohydrate / tetrahydrofuran; water / 3 h / 20 °C

4.1: triethylamine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C / Inert atmosphere

5.1: methanol; lithium hydroxide monohydrate / tetrahydrofuran; water / 0.5 h / 20 °C

With methanol; dmap; lithium hydroxide monohydrate; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water;
DOI:10.1002/chem.201400046

Reference yield:

: 481072-37-1
(S)-3-(p-benzyloxyphenyl)lactic acid methyl ester

: 1242104-15-9
(S)-2-((S)-2-(benzyloxy)-3-(4-(benzyloxy)phenyl)propanamido)-3-phenylpropanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere

1.2: 1.5 h / 20 °C / Inert atmosphere

2.1: methanol; lithium hydroxide monohydrate / tetrahydrofuran; water / 3 h / 20 °C

3.1: triethylamine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C / Inert atmosphere

4.1: methanol; lithium hydroxide monohydrate / tetrahydrofuran; water / 0.5 h / 20 °C

With methanol; dmap; lithium hydroxide monohydrate; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; dichloromethane; water;
DOI:10.1002/chem.201400046