tert-Butyl({(5S)-5-[(4-fluorophenoxy)methyl]oxolan-2-yl}oxy)dimethylsilane

Base Information

Chemical Name:tert-Butyl({(5S)-5-[(4-fluorophenoxy)methyl]oxolan-2-yl}oxy)dimethylsilane
CAS No.:220623-68-7
Molecular Formula:C₁₇H₂₇FO₃Si
Molecular Weight:326.483
Hs Code.:
DSSTox Substance ID:DTXSID80573005

Synonyms:220623-68-7;tert-Butyl(((5S)-5-((4-fluorophenoxy)methyl)tetrahydrofuran-2-yl)oxy)dimethylsilane;SCHEMBL7022831;DTXSID80573005;tert-Butyl({(5S)-5-[(4-fluorophenoxy)methyl]oxolan-2-yl}oxy)dimethylsilane

Suppliers and Price of tert-Butyl({(5S)-5-[(4-fluorophenoxy)methyl]oxolan-2-yl}oxy)dimethylsilane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 1 raw suppliers

Chemical Property of tert-Butyl({(5S)-5-[(4-fluorophenoxy)methyl]oxolan-2-yl}oxy)dimethylsilane

Chemical Property:

Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:326.17134942
Heavy Atom Count:22
Complexity:348

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)[Si](C)(C)OC1CCC(O1)COC2=CC=C(C=C2)F
Isomeric SMILES:CC(C)(C)[Si](C)(C)OC1CC[C@H](O1)COC2=CC=C(C=C2)F

Technology Process of tert-Butyl({(5S)-5-[(4-fluorophenoxy)methyl]oxolan-2-yl}oxy)dimethylsilane

There total 6 articles about tert-Butyl({(5S)-5-[(4-fluorophenoxy)methyl]oxolan-2-yl}oxy)dimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 32780-06-6
(5S)-5-(hydroxymethyl)-2-oxo-tetrahydrofuran

: 220623-68-7
(5S)-5-(4-fluorophenoxymethyl)-2-(tert-butyldimethylsiloxy)tetrahydrofuran

Guidance literature:: Multi-step reaction with 3 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 5 h / 20 °C / Reflux; Inert atmosphere; Large scale

2: diisobutylaluminium hydride / dichloromethane; toluene / 2 h / -78 °C / Inert atmosphere; Large scale

3: 1H-imidazole; dmap / dichloromethane / 20 °C / Inert atmosphere; Large scale

With 1H-imidazole; dmap; di-isopropyl azodicarboxylate; diisobutylaluminium hydride; triphenylphosphine; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/op980209l