tert-butyl 5-(6-hydroxy-7-methoxy-2-(3-(2-morpholinoacetamido)phenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate

Base Information

Chemical Name:tert-butyl 5-(6-hydroxy-7-methoxy-2-(3-(2-morpholinoacetamido)phenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate
CAS No.:911418-56-9
Molecular Formula:C₃₃H₃₅N₇O₆
Molecular Weight:625.684
Hs Code.:

Synonyms:tert-butyl 5-(6-hydroxy-7-methoxy-2-(3-(2-morpholinoacetamido)phenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate

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Chemical Property of tert-butyl 5-(6-hydroxy-7-methoxy-2-(3-(2-morpholinoacetamido)phenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate

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Technology Process of tert-butyl 5-(6-hydroxy-7-methoxy-2-(3-(2-morpholinoacetamido)phenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate

There total 7 articles about tert-butyl 5-(6-hydroxy-7-methoxy-2-(3-(2-morpholinoacetamido)phenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 110-91-8,99108-56-2
morpholine

: 911418-55-8
tert-butyl 5-(6-acetoxy-2-(3-aminophenyl)-7-methoxyquinazolin-4-ylamino)-1H-indazole-1-carboxylate

: 79-04-9
chloroacetyl chloride

: 911418-56-9
tert-butyl 5-(6-hydroxy-7-methoxy-2-(3-(2-morpholinoacetamido)phenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate

Guidance literature:: tert-butyl 5-(6-acetoxy-2-(3-aminophenyl)-7-methoxyquinazolin-4-ylamino)-1H-indazole-1-carboxylate; chloroacetyl chloride; With sodium hydrogencarbonate; In tetrahydrofuran; ethyl acetate; at 20 ℃; for 5h;

morpholine; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 4h;

With methanol; ammonium hydroxide; at 20 ℃; for 24h;

Reference yield:

: C₃₅H₃₇N₇O₇

: 911418-56-9
tert-butyl 5-(6-hydroxy-7-methoxy-2-(3-(2-morpholinoacetamido)phenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate

Guidance literature:: With ammonia; In methanol; water; at 20 ℃; for 24h;

Reference yield:

: 911418-46-7
7-methoxy-2-(3-nitrophenyl)-4-oxo-3,4-dihydroquinazolin-6-yl acetate

: 911418-56-9
tert-butyl 5-(6-hydroxy-7-methoxy-2-(3-(2-morpholinoacetamido)phenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: thionyl chloride; N,N-dimethyl-formamide / 2.5 h / Heating / reflux

2: isopropyl alcohol / 5 h / Heating / reflux

3: hydrogen / palladium over charcoal / methanol / 48 h / 20 °C

4: sodium hydrogencarbonate / tetrahydrofuran; water; ethyl acetate / 5 h / 20 °C

5: sodium hydrogencarbonate / tetrahydrofuran; N,N-dimethyl-formamide / 4 h / 20 °C

6: methanol; ammonia; water / 24 h / 20 °C

With methanol; thionyl chloride; ammonia; water; hydrogen; sodium hydrogencarbonate; N,N-dimethyl-formamide; palladium over charcoal; In tetrahydrofuran; methanol; water; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;