N-{2,4-difluoro-3-[5-(4-pyrimidinyl)-2-(4-morpholinyl)-1,3-thiazol-4-yl]phenyl}-1-propanesulfonamide

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Chemical Name:N-{2,4-difluoro-3-[5-(4-pyrimidinyl)-2-(4-morpholinyl)-1,3-thiazol-4-yl]phenyl}-1-propanesulfonamide
CAS No.:1307271-00-6
Molecular Formula:C₂₀H₂₁F₂N₅O₃S₂
Molecular Weight:481.547
Hs Code.:

Synonyms:N-{2,4-difluoro-3-[5-(4-pyrimidinyl)-2-(4-morpholinyl)-1,3-thiazol-4-yl]phenyl}-1-propanesulfonamide

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Chemical Property of N-{2,4-difluoro-3-[5-(4-pyrimidinyl)-2-(4-morpholinyl)-1,3-thiazol-4-yl]phenyl}-1-propanesulfonamide

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Technology Process of N-{2,4-difluoro-3-[5-(4-pyrimidinyl)-2-(4-morpholinyl)-1,3-thiazol-4-yl]phenyl}-1-propanesulfonamide

There total 4 articles about N-{2,4-difluoro-3-[5-(4-pyrimidinyl)-2-(4-morpholinyl)-1,3-thiazol-4-yl]phenyl}-1-propanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1307272-51-0
N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(4-morpholinyl)-1,3-thiazol-4-yl]-2,4-difluorophenyl}-1-propanesulfonamide

: 1307271-00-6
N-{2,4-difluoro-3-[5-(4-pyrimidinyl)-2-(4-morpholinyl)-1,3-thiazol-4-yl]phenyl}-1-propanesulfonamide

Guidance literature:: With ammonium formate; 20% palladium hydroxide-activated charcoal; In methanol; ethyl acetate; at 20 - 60 ℃; for 1h; Inert atmosphere;

Reference yield:

: 13036-57-2
2-chloro-4-methylpyrimidine

: 1307271-00-6
N-{2,4-difluoro-3-[5-(4-pyrimidinyl)-2-(4-morpholinyl)-1,3-thiazol-4-yl]phenyl}-1-propanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / -10 °C / Inert atmosphere

1.2: 0.5 h / -10 °C / Inert atmosphere

2.1: N-Bromosuccinimide / ISOPROPYLAMIDE / 0.5 h / 0 °C / Inert atmosphere

2.2: 4 h / 60 °C / Inert atmosphere

3.1: ammonium formate / 20% palladium hydroxide-activated charcoal / ethyl acetate; methanol / 1 h / 20 - 60 °C / Inert atmosphere

With N-Bromosuccinimide; ammonium formate; lithium hexamethyldisilazane; 20% palladium hydroxide-activated charcoal; In tetrahydrofuran; methanol; ISOPROPYLAMIDE; ethyl acetate;

Reference yield:

: 1186223-50-6
methyl 2,6-difluoro-3-(propylsulfonamido)benzoate

: 1307271-00-6
N-{2,4-difluoro-3-[5-(4-pyrimidinyl)-2-(4-morpholinyl)-1,3-thiazol-4-yl]phenyl}-1-propanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / -10 °C / Inert atmosphere

1.2: 0.5 h / -10 °C / Inert atmosphere

2.1: N-Bromosuccinimide / ISOPROPYLAMIDE / 0.5 h / 0 °C / Inert atmosphere

2.2: 4 h / 60 °C / Inert atmosphere

3.1: ammonium formate / 20% palladium hydroxide-activated charcoal / ethyl acetate; methanol / 1 h / 20 - 60 °C / Inert atmosphere

With N-Bromosuccinimide; ammonium formate; lithium hexamethyldisilazane; 20% palladium hydroxide-activated charcoal; In tetrahydrofuran; methanol; ISOPROPYLAMIDE; ethyl acetate;