1,1-dimethylethyl (2S)-2-methyl-4-{[4-(methylamino)phenyl]methyl}-1-piperazinecarboxylate

Base Information

• Chemical Name: 1,1-dimethylethyl (2S)-2-methyl-4-{[4-(methylamino)phenyl]methyl}-1-piperazinecarboxylate
• CAS No.: 960121-92-0
• Molecular Formula: C₁₈H₂₉N₃O₂
• Molecular Weight: 319.447
• Mol file: 960121-92-0.mol

Synonyms:1,1-dimethylethyl (2S)-2-methyl-4-{[4-(methylamino)phenyl]methyl}-1-piperazinecarboxylate

Chemical Property of 1,1-dimethylethyl (2S)-2-methyl-4-{[4-(methylamino)phenyl]methyl}-1-piperazinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,1-dimethylethyl (2S)-2-methyl-4-{[4-(methylamino)phenyl]methyl}-1-piperazinecarboxylate

There total 4 articles about 1,1-dimethylethyl (2S)-2-methyl-4-{[4-(methylamino)phenyl]methyl}-1-piperazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + tert-butyl (2S)-4-[(4-aminophenyl)methyl]-2-methylpiperazine-1-carboxylate (960121-91-9) → 1,1-dimethylethyl (2S)-2-methyl-4-{[4-(methylamino)phenyl]methyl}-1-piperazinecarboxylate (960121-92-0)

Guidance literature:

formaldehyd; tert-butyl (2S)-4-[(4-aminophenyl)methyl]-2-methylpiperazine-1-carboxylate; With sodium methylate; In methanol; at 50 ℃; for 24h;

With sodium tetrahydroborate; In methanol; at 50 ℃; for 1h;

With water; In dichloromethane; Product distribution / selectivity;

Reference yield:

1,1-dimethylethyl (2S)-2-methyl-4-[(4-nitrophenyl)methyl]-1-piperazinecarboxylate (960121-90-8) → 1,1-dimethylethyl (2S)-2-methyl-4-{[4-(methylamino)phenyl]methyl}-1-piperazinecarboxylate (960121-92-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: iron; ammonium chloride / methanol; water / 2 h / 80 °C

2.1: sodium methylate / methanol / 24 h / 50 °C

2.2: 1 h / 50 °C

With sodium methylate; iron; ammonium chloride; In methanol; water;

Reference yield:

4-nitrobenzaldehdye (555-16-8) → 1,1-dimethylethyl (2S)-2-methyl-4-{[4-(methylamino)phenyl]methyl}-1-piperazinecarboxylate (960121-92-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C

2.1: iron; ammonium chloride / methanol; water / 2 h / 80 °C

3.1: sodium methylate / methanol / 24 h / 50 °C

3.2: 1 h / 50 °C

With sodium methylate; sodium tris(acetoxy)borohydride; iron; ammonium chloride; In methanol; water; 1,2-dichloro-ethane;

upstream raw materials:

formaldehyd

tert-butyl (2S)-4-[(4-aminophenyl)methyl]-2-methylpiperazine-1-carboxylate

1,1-dimethylethyl (2S)-2-methyl-4-[(4-nitrophenyl)methyl]-1-piperazinecarboxylate

4-nitrobenzaldehdye

Downstream raw materials:

1,1-dimethylethyl (2S)-4-({4-[({6-[(4-fluorophenyl)oxy]-3-pyridinyl}carbonyl)(methyl)amino]phenyl}methyl)-2-methyl-1-piperazinecarboxylate

1,1-dimethylethyl (2S)-4-({4-[{[1-(4-fluorophenyl)-4-piperidinyl]carbonyl}(methyl)amino]phenyl}methyl)-2-methyl-1-piperazinecarboxylate

1,1-dimethylethyl (2S)-4-({4-[{[6-(3-fluorophenyl)-3-pyridinyl]carbonyl}(methyl)amino]phenyl}methyl)-2-methyl-1-piperazinecarboxylate

1,1-dimethylethyl (2S)-4-({4-[{[6-(4-fluorophenyl)-2-methyl-3-pyridinyl]carbonyl}(methyl)amino]phenyl}methyl)-2-methyl-1-piperazinecarboxylate