2-Sulfanyl-5H,6H,7H-cyclopenta-[b]pyridine-3-carbonitrile

Base Information

• Chemical Name: 2-Sulfanyl-5H,6H,7H-cyclopenta-[b]pyridine-3-carbonitrile
• CAS No.: 154384-01-7
• Molecular Formula: C₉H₈N₂S
• Molecular Weight: 176.242
• Mol file: 154384-01-7.mol

Synonyms:2-thioxo-2,5,6,7-tetrahydro-1H-cyclopenta[b]pyridine-3-carbonitrile

Chemical Property of 2-Sulfanyl-5H,6H,7H-cyclopenta-[b]pyridine-3-carbonitrile

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Sulfanyl-5H,6H,7H-cyclopenta-[b]pyridine-3-carbonitrile

There total 3 articles about 2-Sulfanyl-5H,6H,7H-cyclopenta-[b]pyridine-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

Cyanothioacetamide (7357-70-2) + sodium (2-oxocyclopentylidene)methenolate → 2-thioxo-2,5,6,7-tetrahydro-1H-cyclopenta[b]pyridine-3-carbonitrile (154384-01-7)

Guidance literature:

With piperdinium acetate; In water; for 0.166667h; Heating;

DOI:10.1016/S0040-4020(01)80745-6

Reference yield: 52.0%

Cyanothioacetamide (7357-70-2) + 2-(hydroxymethylene)cyclopentanone, sodium salt → 2-thioxo-2,5,6,7-tetrahydro-1H-cyclopenta[b]pyridine-3-carbonitrile (154384-01-7)

Guidance literature:

In ethanol; acetic acid; for 3h; Heating;

DOI:10.1007/BF01169725

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + Cyanothioacetamide (7357-70-2) + cyclopentanone (120-92-3) → 2-thioxo-2,5,6,7-tetrahydro-1H-cyclopenta[b]pyridine-3-carbonitrile (154384-01-7)

Guidance literature:

formaldehyd; cyclopentanone; With potassium hydroxide; In methanol;

Cyanothioacetamide; In methanol;

DOI:10.1016/j.bmc.2016.11.041

upstream raw materials:

Cyanothioacetamide

formaldehyd

cyclopentanone

Downstream raw materials:

3-amino-2-cyano-5,6-trimethylenethieno<2,3-b>pyridine

3-amino-2-carbamoyl-5,6-trimethylenethienopyridine

(3-Amino-6,7-dihydro-5H-cyclopenta[b]thieno[3,2-e]pyridin-2-yl)-phenyl-methanone

3-amino-6,7-dihydro-5H-cyclopenta[b]thieno[3,2-e]pyridine-2-carboxylic acid ethyl ester