diisopropyl (S)-(((1-(benzyloxy)-3-(trityloxy)propan-2-yl)oxy)methyl)phosphonate

Base Information

Chemical Name:diisopropyl (S)-(((1-(benzyloxy)-3-(trityloxy)propan-2-yl)oxy)methyl)phosphonate
CAS No.:941293-47-6
Molecular Formula:C₃₆H₄₃O₆P
Molecular Weight:602.708
Hs Code.:

Synonyms:diisopropyl (S)-(((1-(benzyloxy)-3-(trityloxy)propan-2-yl)oxy)methyl)phosphonate

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Chemical Property of diisopropyl (S)-(((1-(benzyloxy)-3-(trityloxy)propan-2-yl)oxy)methyl)phosphonate

Chemical Property:

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Technology Process of diisopropyl (S)-(((1-(benzyloxy)-3-(trityloxy)propan-2-yl)oxy)methyl)phosphonate

There total 4 articles about diisopropyl (S)-(((1-(benzyloxy)-3-(trityloxy)propan-2-yl)oxy)methyl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 35717-98-7
bis(2-propyl)-p-toluenesulfonyloxymethylphosphonate

: 941293-47-6
diisopropyl (S)-(((1-(benzyloxy)-3-(trityloxy)propan-2-yl)oxy)methyl)phosphonate

Guidance literature:: (S)-1-(benzyloxy)-3-trityloxypropan-2-ol; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 1.33333h; Heating / reflux;

bis(2-propyl)-p-toluenesulfonyloxymethylphosphonate; In tetrahydrofuran; at 20 ℃; for 72h;

With acetic acid; In tetrahydrofuran; Product distribution / selectivity;

Reference yield:

: 83526-68-5
(S)-1-(benzyloxy)-3-trityloxypropan-2-ol

: 98432-80-5
diisopropyl (bromomethyl)phosphonate

: 941293-47-6
diisopropyl (S)-(((1-(benzyloxy)-3-(trityloxy)propan-2-yl)oxy)methyl)phosphonate

Guidance literature:: (S)-1-(benzyloxy)-3-trityloxypropan-2-ol; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.25h;

diisopropyl (bromomethyl)phosphonate; In N,N-dimethyl-formamide; at 20 ℃; for 48h;
DOI:10.1002/cmdc.201500322

Reference yield:

: 129940-50-7
(S)-tritylglycidol

: 941293-47-6
diisopropyl (S)-(((1-(benzyloxy)-3-(trityloxy)propan-2-yl)oxy)methyl)phosphonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 2 h / 100 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 0 °C

2.2: 48 h / 20 °C

With sodium hydride; In N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201500322