diisopropyl (R)-((((1-benzyloxy)-3-hydroxypropan-2-yl)oxy)methyl)phosphonate

Base Information

• Chemical Name: diisopropyl (R)-((((1-benzyloxy)-3-hydroxypropan-2-yl)oxy)methyl)phosphonate
• CAS No.: 941293-70-5
• Molecular Formula: C₁₇H₂₉O₆P
• Molecular Weight: 360.387
• Mol file: 941293-70-5.mol

Synonyms:diisopropyl (R)-((((1-benzyloxy)-3-hydroxypropan-2-yl)oxy)methyl)phosphonate

Chemical Property of diisopropyl (R)-((((1-benzyloxy)-3-hydroxypropan-2-yl)oxy)methyl)phosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diisopropyl (R)-((((1-benzyloxy)-3-hydroxypropan-2-yl)oxy)methyl)phosphonate

There total 6 articles about diisopropyl (R)-((((1-benzyloxy)-3-hydroxypropan-2-yl)oxy)methyl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diisopropyl (S)-(((1-(benzyloxy)-3-(trityloxy)propan-2-yl)oxy)methyl)phosphonate (941293-47-6) → diisopropyl (R)-((((1-benzyloxy)-3-hydroxypropan-2-yl)oxy)methyl)phosphonate (941293-70-5)

Guidance literature:

With water; hydrogenchloride; In 1,4-dioxane; for 4h;

Reference yield:

(R)-3-benzyloxy-1,2-propanediol (56552-80-8) → diisopropyl (R)-((((1-benzyloxy)-3-hydroxypropan-2-yl)oxy)methyl)phosphonate (941293-70-5)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine; dmap / dichloromethane / 12 h / 20 °C

2: sodium hydride / tetrahydrofuran / 12 h / 0 - 20 °C

3: toluene-4-sulfonic acid / methanol / 5 h

With dmap; sodium hydride; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1021/acsmedchemlett.0c00090

Reference yield:

(S)-1-Benzyloxy-3-[(4-methoxy-phenyl)-diphenyl-methoxy]-propan-2-ol → diisopropyl (R)-((((1-benzyloxy)-3-hydroxypropan-2-yl)oxy)methyl)phosphonate (941293-70-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / tetrahydrofuran / 12 h / 0 - 20 °C

2: toluene-4-sulfonic acid / methanol / 5 h

With sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; methanol;

DOI:10.1021/acsmedchemlett.0c00090

upstream raw materials:

diisopropyl (S)-(((1-(benzyloxy)-3-(trityloxy)propan-2-yl)oxy)methyl)phosphonate

benzyl alcohol

(S)-1-(benzyloxy)-3-trityloxypropan-2-ol

(R)-3-benzyloxy-1,2-propanediol

Downstream raw materials:

(S)-3-(benzyloxy)-2-[(diisopropoxyphosphoryl)methoxy]propyl 4-methylbenzenesulphonate

(S)-1-O-benzyl-2-O-<(diisopropylphosphono)methyl>-3-fluoro-1,2-propanediol

(S)-2-[(diisopropoxyphosphoryl)methoxy]-3-fluoropropyl 4-methylbenzenesulphonate