98432-80-5

Usage

Uses

Used in Chemical Synthesis:
Diisopropyl bromomethylphosphonate is used as an organophosphorus intermediate for the production of a wide range of organophosphorus compounds. Its unique structure allows it to be a key component in the synthesis of various pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Biochemical Research:
As a biochemical reagent, diisopropyl bromomethylphosphonate plays a crucial role in research and development. It is utilized in various biochemical assays and experiments to study the interactions and mechanisms of organophosphorus compounds with biological systems, contributing to the advancement of scientific knowledge in this field.

InChI:InChI=1/C7H16BrO3P/c1-6(2)10-12(9,5-8)11-7(3)4/h6-7H,5H2,1-4H3

Upstream product

• 116-17-6 triisopropyl phosphite 
• 74-95-3 1,1-dibromomethane 

Downstream Products

• 149210-90-2 Diphenylphosphinylmethanphosphonsaeurediisopropylester 
• 17982-56-8 Azidomethyl-phosphonic acid diisopropyl ester 
• 218444-76-9 1-diisopropyloxyphosphorylmethyl-4-benzyloxy-2-pyridone 
• 933460-58-3 1-{(2S)-2-[(diisopropoxyphosphoryl)methoxy-3-(triphenylmethoxy)]propyl}-5-azacytosine 
• 933460-59-4 N-3-[(diisopropoxyphosphoryl)methyl]-1-[(2S)-2-hydroxy-3-(triphenylmethoxy)propyl]-5-azacytosine 
• 675875-37-3 diisopropyl {[(1R,2R)-1-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-methylcyclopropyl]oxy}methylphosphonate 
• 78463-00-0 diisopropyl (E)-(2-phenylethenyl)phosphonate 
• 312512-51-9 ((E)-2-Phenyl-ethenesulfonylmethanesulfonylmethyl)-phosphonic acid diisopropyl ester 
• 441784-84-5 diisopropyl {[1-({[tert-butyl(diphenyl)silyl]oxy}methyl)cyclopropyl]oxy}methylphosphonate 
• 149228-06-8 Benzol-diisopropoxyphosphorylmethanphosphinsaeureisopropylester 
• 1092093-75-8 7-{(diisopropylphosphoryl)-methyloxy}-3',4',5-trimethoxyflavone 

Relevant academic research and scientific papers

Preparation of halohydrocarbyl phosphonic acid diesters

In a process for the production of halohydrocarbyl phosphonic acid diesters via a Michaelis-Arbuzov type reaction which results in high conversion and selectivity of product with ease of purification; the improvement comprises reacting hydrocarbyl halide with trihdydrocarbyl phosphite in a molar ratio of about 6:1 and in the presence of an effective amount of a polarity lowering additive.

ZUR SYNTHESE UND REAKTIVITAET METHYLENVERBRUECKTER DIPHOSPHORYLVERBINDUNGEN

An improved high-yield Arbusov-type synthesis for diphosphorylmethanes with different substituents on both phosphorus atoms (4, 5, 7) by the reaction of isopropyl diphenylphosphinite or diisopropyl phenylphosphonite with diisopropyl bromomethylphosphonate (1) or isopropyl phenyl-bromomethylphosphinate (2), respectively, is described. 1 and 2 are available in yields of about 50 percent by the reaction of an excess of methylene bromide with triisopropylphosphite or diisopropyl phenylphosphonite, respectively.The metalation of the symmetrical and unsymmetrical diphosphorylmethanes 3-8 with NaH in toluene yields the corresponding carbanionic salts 3A-8A.Their structure and reactivity are investigated by means of 31P NMR spectroscopy and Horner-reactions with benzaldehyde.Regioselective monomethylation at the central carbon atom of 3-7 is performed using the phase-transfer technique.With exception of the phosphono-phosphinate derivative 14, on this way the appropriate 1,1-diphosphorylethanes 13 and 15-17 are obtained in high yield.Key words: diisopropyl bromomethylphosphonate; isopropyl phenyl-bromomethylphosphinate; diphosphorylmethanes; 31P-NMR; HORNER-reactions; 1,1-diphosphorylethanes