(S)-2-{4-[(4-Chloro-benzoylamino)-methyl]-benzenesulfonylamino}-3-methyl-butyric acid

Base Information

• Chemical Name: (S)-2-{4-[(4-Chloro-benzoylamino)-methyl]-benzenesulfonylamino}-3-methyl-butyric acid
• CAS No.: 213474-78-3
• Molecular Formula: C₁₉H₂₁ClN₂O₅S
• Molecular Weight: 424.905
• Mol file: 213474-78-3.mol

Synonyms:(S)-2-{4-[(4-Chloro-benzoylamino)-methyl]-benzenesulfonylamino}-3-methyl-butyric acid

Chemical Property of (S)-2-{4-[(4-Chloro-benzoylamino)-methyl]-benzenesulfonylamino}-3-methyl-butyric acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-{4-[(4-Chloro-benzoylamino)-methyl]-benzenesulfonylamino}-3-methyl-butyric acid

There total 1 articles about (S)-2-{4-[(4-Chloro-benzoylamino)-methyl]-benzenesulfonylamino}-3-methyl-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

L-valine (72-18-4,25609-85-2,7004-03-7,921-10-8) + N-(4-chlorosulfonylphenylmethyl)-4-chlorobenzamide (126571-88-8) → (S)-2-{4-[(4-Chloro-benzoylamino)-methyl]-benzenesulfonylamino}-3-methyl-butyric acid (213474-78-3)

Guidance literature:

With water; triethylamine; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1080/10426509708031609

Reference yield: 65.0%

methanol (67-56-1) + (S)-2-{4-[(4-Chloro-benzoylamino)-methyl]-benzenesulfonylamino}-3-methyl-butyric acid (213474-78-3) → (S)-2-{4-[(4-Chloro-benzoylamino)-methyl]-benzenesulfonylamino}-3-methyl-butyric acid methyl ester (213474-85-2)

Guidance literature:

With thionyl chloride; for 4h; Ambient temperature;

DOI:10.1080/10426509708031609

Reference yield:

(S)-2-{4-[(4-Chloro-benzoylamino)-methyl]-benzenesulfonylamino}-3-methyl-butyric acid (213474-78-3) → 4-Chloro-N-[4-((S)-1-hydrazinocarbonyl-2-methyl-propylsulfamoyl)-benzyl]-benzamide

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / SOCl₂ / 4 h / Ambient temperature

2: 78 percent / hydrazine hydrate / ethanol / 24 h / Ambient temperature

With thionyl chloride; hydrazine hydrate; In ethanol;

DOI:10.1080/10426509708031609

upstream raw materials:

L-valine

N-(4-chlorosulfonylphenylmethyl)-4-chlorobenzamide

Downstream raw materials:

(S)-2-{4-[(4-Chloro-benzoylamino)-methyl]-benzenesulfonylamino}-3-methyl-butyric acid methyl ester