N-<(1,1-dimethylethoxy)carbonyl>-3-<2-<<(phenylmethoxy)carbonyl>amino>-4-thiazolyl>-L-alanine

Base Information

Chemical Name:N-<(1,1-dimethylethoxy)carbonyl>-3-<2-<<(phenylmethoxy)carbonyl>amino>-4-thiazolyl>-L-alanine
CAS No.:135704-24-4
Molecular Formula:C₁₉H₂₃N₃O₆S
Molecular Weight:421.474
Hs Code.:

Synonyms:N-<(1,1-dimethylethoxy)carbonyl>-3-<2-<<(phenylmethoxy)carbonyl>amino>-4-thiazolyl>-L-alanine

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Chemical Property of N-<(1,1-dimethylethoxy)carbonyl>-3-<2-<<(phenylmethoxy)carbonyl>amino>-4-thiazolyl>-L-alanine

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Technology Process of N-<(1,1-dimethylethoxy)carbonyl>-3-<2-<<(phenylmethoxy)carbonyl>amino>-4-thiazolyl>-L-alanine

There total 6 articles about N-<(1,1-dimethylethoxy)carbonyl>-3-<2-<<(phenylmethoxy)carbonyl>amino>-4-thiazolyl>-L-alanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 150114-17-3
phenylmethyl N-<(1,1-dimethylethoxy)carbonyl>-3-<2-<<(phenylmethoxy)carbonyl>amino>-4-thiazolyl>-L-alaninate

: 135704-24-4
N-<(1,1-dimethylethoxy)carbonyl>-3-<2-<<(phenylmethoxy)carbonyl>amino>-4-thiazolyl>-L-alanine

Guidance literature:: With potassium hydroxide; In ethanol; for 4h; Ambient temperature;
DOI:10.1021/jm00092a006

Reference yield:

: 150114-17-3
(R)-3-(2-Benzyloxycarbonylamino-thiazol-4-yl)-2-tert-butoxycarbonylamino-propionic acid benzyl ester

: 135704-23-3,135704-24-4
(R)-3-(2-Benzyloxycarbonylamino-thiazol-4-yl)-2-tert-butoxycarbonylamino-propionic acid

Guidance literature:: With potassium hydroxide; In ethanol; for 4h; Ambient temperature;
DOI:10.1021/jm00092a006

Reference yield:

: 132286-86-3
(R)-3-(2-Amino-thiazol-4-yl)-2-tert-butoxycarbonylamino-propionic acid benzyl ester

: 135704-23-3,135704-24-4
(R)-3-(2-Benzyloxycarbonylamino-thiazol-4-yl)-2-tert-butoxycarbonylamino-propionic acid

Guidance literature:: Multi-step reaction with 2 steps

1: aq. sodium bicarbonate / tetrahydrofuran; CH₂Cl₂ / Ambient temperature

2: aq. KOH / ethanol / 4 h / Ambient temperature

With potassium hydroxide; sodium hydrogencarbonate; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm00092a006