5-chloro-thiophene-2-carboxylic acid[(S)-2-[3-(5-chloro-1-methyl-2-oxo-1 ,2-dihydro-pyridin-3-yl)-2-ethyl-benzenesulfonylamino]-3-((S)-3-methyl-morpholin-4-yl)-3-oxo-propyl]-amide

Base Information

Chemical Name:5-chloro-thiophene-2-carboxylic acid[(S)-2-[3-(5-chloro-1-methyl-2-oxo-1 ,2-dihydro-pyridin-3-yl)-2-ethyl-benzenesulfonylamino]-3-((S)-3-methyl-morpholin-4-yl)-3-oxo-propyl]-amide
CAS No.:1184298-10-9
Molecular Formula:C₂₇H₃₀Cl₂N₄O₆S₂
Molecular Weight:641.596
Hs Code.:

5-chloro-thiophene-2-carboxylic acid[(S)-2-[3-(5-chloro-1-methyl-2-oxo-1 ,2-dihydro-pyridin-3-yl)-2-ethyl-benzenesulfonylamino]-3-((S)-3-methyl-morpholin-4-yl)-3-oxo-propyl]-amide

Synonyms:5-chloro-thiophene-2-carboxylic acid[(S)-2-[3-(5-chloro-1-methyl-2-oxo-1 ,2-dihydro-pyridin-3-yl)-2-ethyl-benzenesulfonylamino]-3-((S)-3-methyl-morpholin-4-yl)-3-oxo-propyl]-amide

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Chemical Property of 5-chloro-thiophene-2-carboxylic acid[(S)-2-[3-(5-chloro-1-methyl-2-oxo-1 ,2-dihydro-pyridin-3-yl)-2-ethyl-benzenesulfonylamino]-3-((S)-3-methyl-morpholin-4-yl)-3-oxo-propyl]-amide

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Technology Process of 5-chloro-thiophene-2-carboxylic acid[(S)-2-[3-(5-chloro-1-methyl-2-oxo-1 ,2-dihydro-pyridin-3-yl)-2-ethyl-benzenesulfonylamino]-3-((S)-3-methyl-morpholin-4-yl)-3-oxo-propyl]-amide

There total 11 articles about 5-chloro-thiophene-2-carboxylic acid[(S)-2-[3-(5-chloro-1-methyl-2-oxo-1 ,2-dihydro-pyridin-3-yl)-2-ethyl-benzenesulfonylamino]-3-((S)-3-methyl-morpholin-4-yl)-3-oxo-propyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 1184298-13-2
3-(5-chloro-1-methyl-2-oxo-1 ,2-dihydro-pyridin-3-yl)-2-ethyl-benzenesulfonyl chloride

: 1184297-38-8
5-chloro-thiophene-2-carboxylic acid [(S)-2-amino-3-((S)-3-methyl-morpholin-4-yl)-3-oxo-propyl]-amide

: 1184298-10-9
5-chloro-thiophene-2-carboxylic acid[(S)-2-[3-(5-chloro-1-methyl-2-oxo-1 ,2-dihydro-pyridin-3-yl)-2-ethyl-benzenesulfonylamino]-3-((S)-3-methyl-morpholin-4-yl)-3-oxo-propyl]-amide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane;

Reference yield:

: 81971-38-2
3-bromo-1-methyl-1H-pyridin-2-one

: 1184298-10-9
5-chloro-thiophene-2-carboxylic acid[(S)-2-[3-(5-chloro-1-methyl-2-oxo-1 ,2-dihydro-pyridin-3-yl)-2-ethyl-benzenesulfonylamino]-3-((S)-3-methyl-morpholin-4-yl)-3-oxo-propyl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1: barium hydroxide octahydrate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; dimethyl sulfoxide / 3 h / 110 °C / Inert atmosphere

2: sulfuryl dichloride; water; acetic acid / dichloromethane

3: N-ethyl-N,N-diisopropylamine / 1,4-dioxane; dichloromethane

With sulfuryl dichloride; barium hydroxide octahydrate; water; acetic acid; N-ethyl-N,N-diisopropylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide;

Reference yield:

: 13466-43-8
3-bromo-pyridin-2-ol

: 1184298-10-9
5-chloro-thiophene-2-carboxylic acid[(S)-2-[3-(5-chloro-1-methyl-2-oxo-1 ,2-dihydro-pyridin-3-yl)-2-ethyl-benzenesulfonylamino]-3-((S)-3-methyl-morpholin-4-yl)-3-oxo-propyl]-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0 °C / Inert atmosphere

1.2: 20 °C

2.1: barium hydroxide octahydrate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; dimethyl sulfoxide / 3 h / 110 °C / Inert atmosphere

3.1: sulfuryl dichloride; water; acetic acid / dichloromethane

4.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane; dichloromethane

With sulfuryl dichloride; barium hydroxide octahydrate; water; sodium hydride; acetic acid; N-ethyl-N,N-diisopropylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;