3-(5-chloro-1-methyl-2-oxo-1 ,2-dihydro-pyridin-3-yl)-2-ethyl-benzenesulfonyl chloride

Base Information

Chemical Name:3-(5-chloro-1-methyl-2-oxo-1 ,2-dihydro-pyridin-3-yl)-2-ethyl-benzenesulfonyl chloride
CAS No.:1184298-13-2
Molecular Formula:C₁₄H₁₃Cl₂NO₃S
Molecular Weight:346.234
Hs Code.:

Synonyms:3-(5-chloro-1-methyl-2-oxo-1 ,2-dihydro-pyridin-3-yl)-2-ethyl-benzenesulfonyl chloride

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Chemical Property of 3-(5-chloro-1-methyl-2-oxo-1 ,2-dihydro-pyridin-3-yl)-2-ethyl-benzenesulfonyl chloride

Chemical Property:

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Technology Process of 3-(5-chloro-1-methyl-2-oxo-1 ,2-dihydro-pyridin-3-yl)-2-ethyl-benzenesulfonyl chloride

There total 7 articles about 3-(5-chloro-1-methyl-2-oxo-1 ,2-dihydro-pyridin-3-yl)-2-ethyl-benzenesulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1184298-12-1
3-(3-benzylsulfanyl-2-ethyl-phenyl)-1-methyl-1H-pyridin-2-one

: 1184298-13-2
3-(5-chloro-1-methyl-2-oxo-1 ,2-dihydro-pyridin-3-yl)-2-ethyl-benzenesulfonyl chloride

Guidance literature:: With sulfuryl dichloride; water; acetic acid; In dichloromethane;

Reference yield:

: 13466-43-8
3-bromo-pyridin-2-ol

: 1184298-13-2
3-(5-chloro-1-methyl-2-oxo-1 ,2-dihydro-pyridin-3-yl)-2-ethyl-benzenesulfonyl chloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0 °C / Inert atmosphere

1.2: 20 °C

2.1: barium hydroxide octahydrate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; dimethyl sulfoxide / 3 h / 110 °C / Inert atmosphere

3.1: sulfuryl dichloride; water; acetic acid / dichloromethane

With sulfuryl dichloride; barium hydroxide octahydrate; water; sodium hydride; acetic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 108-36-1
1,3-dibromobenzene

: 1184298-13-2
3-(5-chloro-1-methyl-2-oxo-1 ,2-dihydro-pyridin-3-yl)-2-ethyl-benzenesulfonyl chloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / -78 - -65 °C / Inert atmosphere

1.2: 0.33 h / Saturated solution

2.1: n-butyllithium / tetrahydrofuran; n-heptane / 0.25 h / -78 °C

2.2: 0.5 h / -78 °C / Inert atmosphere

2.3: 1.5 h / -78 °C

3.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 2.5 h / 110 °C / Inert atmosphere

4.1: barium hydroxide octahydrate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; dimethyl sulfoxide / 3 h / 110 °C / Inert atmosphere

5.1: sulfuryl dichloride; water; acetic acid / dichloromethane

With n-butyllithium; sulfuryl dichloride; barium hydroxide octahydrate; water; potassium acetate; acetic acid; lithium diisopropyl amide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; n-heptane; dichloromethane; ethylbenzene; water; dimethyl sulfoxide;