4-(3'-hydroxy-4'-methyl-4'-phenylsulfanyl-pentanoylamino)-4-methyl-pentanoic acid

Base Information

• Chemical Name: 4-(3'-hydroxy-4'-methyl-4'-phenylsulfanyl-pentanoylamino)-4-methyl-pentanoic acid
• CAS No.: 910865-31-5
• Molecular Formula: C₁₈H₂₇NO₄S
• Molecular Weight: 353.483
• Mol file: 910865-31-5.mol

Synonyms:4-(3'-hydroxy-4'-methyl-4'-phenylsulfanyl-pentanoylamino)-4-methyl-pentanoic acid

Chemical Property of 4-(3'-hydroxy-4'-methyl-4'-phenylsulfanyl-pentanoylamino)-4-methyl-pentanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(3'-hydroxy-4'-methyl-4'-phenylsulfanyl-pentanoylamino)-4-methyl-pentanoic acid

There total 8 articles about 4-(3'-hydroxy-4'-methyl-4'-phenylsulfanyl-pentanoylamino)-4-methyl-pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

methyl 4-(3'-hydroxy-4'-methyl-4'-phenylsulfanyl-pentanoylamino)-4-methyl-pentanoate (910865-30-4) → 4-(3'-hydroxy-4'-methyl-4'-phenylsulfanyl-pentanoylamino)-4-methyl-pentanoic acid (910865-31-5)

Guidance literature:

With potassium hydroxide; water; In methanol; at 20 ℃;

DOI:10.1039/b606882k

Reference yield:

tert-butyl 4-methyl-4-nitropentanoate (627539-06-4) → 4-(3'-hydroxy-4'-methyl-4'-phenylsulfanyl-pentanoylamino)-4-methyl-pentanoic acid (910865-31-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 60 percent / H₂ / Raney nickiel / ethanol

2: 3.60 g / triethylamine / tetrahydrofuran / 20 °C

3: 69 percent / SOCl₂ / 48 h / 40 °C

4: 82 percent / KOH; H₂O / methanol / 20 °C

With potassium hydroxide; thionyl chloride; water; hydrogen; triethylamine; Raney nickiel; In tetrahydrofuran; methanol; ethanol;

DOI:10.1039/b606882k

Reference yield:

3-hydroxy-4-methyl-4-(phenylthio)pentanoic acid (910865-10-0) → 4-(3'-hydroxy-4'-methyl-4'-phenylsulfanyl-pentanoylamino)-4-methyl-pentanoic acid (910865-31-5)

Guidance literature:

Multi-step reaction with 4 steps

1: DCC / tetrahydrofuran / 20 °C

2: 3.60 g / triethylamine / tetrahydrofuran / 20 °C

3: 69 percent / SOCl₂ / 48 h / 40 °C

4: 82 percent / KOH; H₂O / methanol / 20 °C

With potassium hydroxide; thionyl chloride; water; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol;

DOI:10.1039/b606882k

upstream raw materials:

methyl 4-(3'-hydroxy-4'-methyl-4'-phenylsulfanyl-pentanoylamino)-4-methyl-pentanoate

ethyl 3-hydroxy-4-methyl-4-(phenylthio)pentanoate

3-hydroxy-4-methyl-4-(phenylthio)pentanoic acid

tert-butyl-4-(3'-hydroxy-4'-methyl-4'-phenylsulfanyl-pentanoylamino)-4-methyl-pentanoate

Downstream raw materials:

tert-butyl 4-[4'-(3''-hydroxy-4''-methyl-4''-phenylsulfanyl-pentanoylamino)-4'-methyl-pentanoylamino]-4-methyl-pentanoate

methyl 4-[4'-(3''-hydroxy-4''-methyl-4''-phenylsulfanyl-pentanoylamino)-4'-methyl-pentanoylamino]-4-methyl-pentanoate

4-[4'-(3''-hydroxy-4''-methyl-4''-phenylsulfanyl-pentanoylamino)-4'-methyl-pentanoylamino]-4-methyl-pentanoic acid

4-[4'-(3''-hydroxy-4''-methyl-4''-phenylsulfanyl-pentanoylamino)-4'-methyl-pentanoylamino]-4-methyl-pentanamide